Photo of Professor Lee

Eva K. Lee

Associate Professor
Director, Center for Operations Research in Medicine and HealthCare
School of Industrial and Systems Engineering
Georgia Institute of Technology
Atlanta, GA 30332-0205
Phone: (404) 894-4962
Fax: (404) 894-2301
Email: eva.lee AT gatech.edu
Co-Director, NSF I/UCRC Center for Health Organization Transformation

Co-Director, Biomedical Informatics Program, NIH-Atlanta Clinical and Translational Science Institute, Emory-Georgia Tech-Morehouse

Personal Biosketch


Affiliations

Research Interests

  • Large-scale optimization - linear/nonlinear mixed integer programming, combinatorial optimization, parallel algorithms.
  • Mathematical theory and modeling - complex/systems modeling, optimization and logistics theory, machine learning and predictive algorithms, decision theory and risk analysis.
  • High-performance computing - information technology, software enterprise design for industrial, biomedicine, and healthcare applications.
  • Biomedicine and clinical research - biomedical modeling, informatics and algorithmic strategies for genomic analysis, health risk prediction, early disease prediction and diagnosis, optimal treatment strategies and drug delivery, healthcare outcome analysis and treatment prediction.
  • Healthcare policy, management, and decision analysis - systems modeling, quality improvement, operations efficiency, organizational transformation.
  • Public health and medical preparedness - emergency response, large-scale dispensing, disease propagation analysis, and economic impact.
  • Homeland security and defense - surveillance and detection, biodefense, radiological emergency preparedness, medical countermeasures, large-scale response logistics, population protection, design of resilient critical infrastructure.
  • Industrial applications - efficiency and quality of services; portfolio optimization, organizational transformation
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Selected Papers

Optimization, Defense (Homeland Security), and Logistics

< List of Selected Papers > < Top of Page >

Biomedicine, Clinical, HealthCare, Public Health

  • EK Lee, CH Chen, F Pietz, B Benecke, Modeling and optimizing the public health infrastructure for emergency response. Interfaces - 2008 Wagner Prize Special Issue. 2008. To appear Sep 2009.
  • EK Lee, Machine learning framework for classification in medicine and biology. Integration of AI and OR Techniques in Constraint Programming for Combinatorial Optimization Problems, 6th International Conference, CPAIOR 2009, Proceedings. WJ van Hoeve, JN Hooker (Eds). Lecture Notes in Computer Science 5547:1-7, Springer 2009.
  • EK Lee, HK Smalley, Y Zhang, F Pietz, B Benecke. Facility location and multi-modality mass dispensing strategies and emergency response for biodefense and infectious disease outbreaks. International Journal on Risk Assessment and Management - Biosecurity Assurance in a Threatening World: Challenges, Explorations, and Breakthroughs. 12(2/3/4):311-351, 2009.
  • MT McCabe, EK Lee, PM Vertino, A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation. Cancer Research 69(1):282-291, 2009.
  • TD Querec, R Akondy, EK Lee, W Cao, HI Nakaya, D Teuwen, A Pirani, K Gernert, J Deng, B Marzolf, K Kennedy, H Wu, S Bennouna, H Olouch, J Miller, RZ Vencio, M Mulligan, A Aderem, R Ahmed, B Pulendran, Systems biology approach predicts the immunogenicity of the yellow fever vaccine in humans. Nature Immunology 10:116-125, 2009.
  • Q Ling, C Pu, EK Lee, A model-driven approach to manage clinical data in relational databases. IEEE Bioinformatics and Biomedicine, Workshop on Biomedical and Health Informatics. 2008.
  • PK Mehta, L Simpson, EK Lee, TA Lyle, ME McConnell, WM Book, Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. Texas Heart Institute Journal 35(3):256-261, 2008.
  • EK Lee, M Zaider, Operations research advances cancer therapeutics. Interfaces - 2007 Franz Edelman Award Issue 38(1):5-25, 2008.
  • A Jayashankar, U Udayasankar, S Sebastian, M Kalra, EK Lee, W Small, MDCT of thoracoabdominal trauma: an evaluation of the success and limitations of primary interpretation using multiplanar reformatted images versus axial images. Emergency Radiology 15(1):29-34, 2008.
  • EK Lee, Optimization-based predictive models in medicine and biology. Optimization in Medicine, Springer New York, Springer Series in Optimization and Its Applications 12:127-151, 2008.
  • EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Data Mining, Systems Analysis, and Optimization in Biomedicine. Editors: O Seref, OE Kundakcioglu and P Pardalos. AIP Conference Proceedings 953:1-42, 2007.
  • EK Lee, Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering - Systems Biology, Bioinformatics, and Computational Biology 35(6):1095-1109, 2007.
  • EK Lee, KD Cha, JO Deasy, Robust optimization to accommodate effects of systematic treatment uncertainties. In Proceedings for International Conference on "The Use of Computers in Radiation Therapy." 6256:1-5, 2007.
  • EK Lee, KD Cha, T Bortfeld, JO Deasy, 4D-Image-Guided treatment planning optimization for managing organ motion in radiotherapy planning. Proceedings for International Conference on "The Use of Computers in Radiation Therapy". 6205:1-5, 2007.
  • FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, DNA motifs associated with aberrant CpG island methylation. Genomics 87:572-579, 2006.
  • EK Lee, S Maheshwary, J Mason, W Glisson, Large-scale dispensing for emergency response to bioterrorism and infectious disease outbreak. Interfaces - OR Applications for Homeland Defense 36(6):591-607, 2006.
  • EK Lee, T Easton, K Gupta, Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research - Computing and Optimization in Medicine and Life Sciences 148:167-187, 2006.
  • EK Lee, T Fox, I Crocker, Simultaneous beam geometry and intensity map optimization in intensity-modulated radiation therapy. International Journal of Radiation Oncology, Biology, Physics 64(1):301-320, 2006.
  • JO Deasy, EK Lee, T Bortfeld, M Langer, K Zakarian, J Alaly, Y Zhang, H Liu, R Mohan, R Ahuja, A Pollack, J Purdy, R Rardin, A collaboratory for radiation therapy treatment planning optimization research. Annals of Operations Research - Computing and Optimization in Medicine and Life Sciences 148:55-63, 2006.
  • EK Lee, S Maheshwary, J Mason, W Glisson, Decision support system for mass dispensing of medications for infectious disease outbreaks and bioterrorist attacks. Annals of Operations Research - Computing and Optimization in Medicine and Life Sciences 148:25-53, 2006.
  • EK Lee, JO Deasy, Optimization in intensity-modulated radiation therapy. SIAG/OPT Views-and-News, Optimization in Medicine 17(2):20-32, 2006.
  • L Simpson, EK Lee, BJ Hott, DJ Vega, WM Book, Long-term results of angioplasty vs stenting in cardiac transplant recipients with allograft vasculopathy. The Journal of Heart and Lung Transplantation 24(9):1211-1217, 2005.
  • EK Lee, S Maheshwary, J Mason, Real-time staff allocation for emergency treatment response of biologic threats and infectious disease outbreak. INFORMS William Pierskalla Best Paper Award on research excellence in HealthCare and Management Science, Nov 2005.
  • EK Lee, R Gallagher, A Campbell, M Prausnitz, Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra. IEEE Transactions on Biomedical Engineering 51(1):82-89, 2004.
  • L Simpson, PK Mehta, BJ Hott, JD Vega, EK Lee and WM Book, Long term results of angioplasty versus stenting In cardiac transplant recipients with allograft vasculopathy, International society for heart and lung transplantation (ISHLT), 2004.
  • FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, Predicting aberrant CpG island methylation. Proceedings of the National Academy of Sciences 100(21):12253-12258, 2003.
  • M Langer, EK Lee, JO Deasy, R Rardin, J Deye, Operations research applied to radiotherapy, an NCI-NSF - sponsored workshop February 7-9, 2002. International Journal of Radiation Oncology, Biology, Physics 57(3):762-768, 2003.
  • EK Lee, M Zaider, Intraoperative dynamic dose optimization in permanent prostate implants. International Journal of Radiation Oncology, Biology, Physics 56(3):854-861, 2003.
  • EK Lee, T Fox, I Crocker, Integer programming applied to Intensity-modulated radiation therapy treatment planning. Annals of Operations Research - Optimization in Medicine 119:165-181, 2003.
  • EK Lee, M Zaider, Mixed integer programming approaches to treatment planning for brachytherapy - application to permanent prostate implants. Annals of Operations Research - Optimization in Medicine 119:147-163, 2003.
  • EK Lee, J Deasy, M Langer, R Rardin, J Deye, F Mahoney, Final report - NCI/NSF workshop on operations research applied to radiation therapy, Washington, DC, February 7-9, 2002. Annals of Operations Research - Optimization in Medicine 119:143-146, 2003.
  • JC Landry, M Koshy, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis, Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction, Proceedings of American Society of Clinical Oncology 22: 297, 2003.
  • EK Lee, AYC Fung, JP Brooks, M Zaider, Automated tumor volume contouring in soft-tissue sarcoma adjuvant brachytherapy treatment. Physics in Medicine and Biology 47(11):1891-1910, 2002.
  • EK Lee, M Zaider, On the determination of an effective planning volume for permanent prostate implants. International Journal of Radiation Oncology, Biology, Physics 49(4):1197-1206, 2001.
  • M Zaider, M Zelefsky, EK Lee, K Zakian, HA Amols, J Dyke, J Koutcher, Treatment planning for prostate implants using magnetic-resonance spectroscopy imaging. International Journal of Radiation Oncology, Biology, Physics 47(4):1085-1096, 2000.
  • CS Wuu, RD Ennis, PB Schiff, EK Lee, M Zaider, Dosimetric and volumetric criteria for selecting source activity and a source type (125I or 103Pd) in the presence of irregular seed placement in permanent prostate implants. International Journal of Radiation Oncology, Biology, Physics 47(3):815-820, 2000.
  • EK Lee, T Fox, I Crocker, Optimization of radiosurgery treatment planning via mixed integer programming. Medical Physics 27(5):995-1004, 2000.
  • EK Lee, R Gallagher, D Silvern, CS Wuu, M Zaider, Treatment planning for brachytherapy: an integer programming model, two computational approaches and experiments with permanent prostate implant planning. Physics in Medicine and Biology 44(1):145-165, 1999.
  • EK Lee, D Silvern, R Gallagher, LG Stabile, RD Ennis, CR Moorthy, M Zaider, Treatment planning for permanent prostate implants: genetic algorithm versus integer programming. Medical & Biological Engineering & Computing 35: Supplement Part 2, 1997.
  • RJ Gallagher, EK Lee, Mixed integer programming optimization models for brachytherapy treatment planning. In: Daniel R. Masys, Ed. Proceedings of the 1997 American Medical Informatics Association Annual Fall Symposium, 278-282, 1997.
  • RJ Gallagher, EK Lee, D Patterson, An optimization model for constrained discriminant analysis and numerical experiments with iris, thyroid, and heart disease datasets. In: Cimino JJ, Ed. Proceedings of the 1996 American Medical Informatics Association, 209-213, 1996.
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Book and Book Chapters

  • GJ Lim and EK Lee, Optimization in Medicine and Biology, Taylor and Francis, Auerbach Publications, 564 pages, 2007.
  • EK Lee and A Sofer, Operations Research in Medicine: Computing and Optimization in Medicine and Life Sciences, Volume 2. Springer Netherlands, Computer Science Series, 270 pages, 2006.
  • EK Lee and A Sofer, Annals of Operations Research -- Optimization in Medicine: Computational and Optimization Approaches to Medical and Life Sciences Applications, Volume 1. Springer Science, Kluwer Academic Publishers, 301 pages, 2003.
  • EK Lee, K Gupta, Algorithms for genomics analysis. In Encyclopedia of Optimization, 2nd edition. Editors: CA Floudas, and PM Pardalos. Springer, The Netherlands 2009. ISBN: 978-0-387-74760-6.
  • EK Lee, TL Wu, Disease diagnosis: optimization based methods. In Encyclopedia of Optimization, 2nd edition. Editors: CA Floudas, and PM Pardalos. Springer, The Netherlands 2009. ISBN: 978-0-387-74760-6.
  • EK Lee, J Mitchell, Integer programming: branch-and-bound methods. In Encyclopedia of Optimization, 2nd edition. Editors: CA Floudas, and PM Pardalos. Springer, The Netherlands 2009. ISBN: 978-0-387-74760-6.
  • EK Lee, TLWu, Classification and disease prediction via mathematical programming. In Handbook in Optimization in Medicine, Chapter 12. Springer Optimization and Its Application, Vol 26. Editors: PM Pardalos and HE Romeijn. 2009. ISBN: 978-0-387-09769-5.
  • EK Lee, K Gupta, Algorithms for genomics analysis. In Handbook in Optimization in Medicine, Chapter 9. Springer Optimization and Its Application, Vol 26. Editors: PM Pardalos and HE Romeijn. 2009. ISBN: 978-0-387-09769-5.
  • EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Optimization in Medicine and Biology, Chapter 1, 3-60. Editors: EK Lee, G Limo, Taylor and Francis, Auerbach Publications, 2008.
  • EK Lee, K Gupta, Algorithms for genomics analysis. In Optimization in Medicine and Biology, Chapter 12, 355-393. Editors: EK Lee, G Limo, Taylor and Francis, Auerbach Publications, 2008.
  • EK Lee, D Lewis, Integer programming for telecommunications. In Handbook of Optimization in Telecommunications, Chapter 3, 67-102. Editors: GC Resende and PM Pardalos. Kluwer Academic Publishers, 2005.
  • EK Lee, M Zaider, Optimization and decision support in brachytherapy treatment planning. In Operations Research and Health Care: A Handbook of Methods and Applications, Chapter 28. (International Series in Operations Research & Management Science) Editors: M Bandeau, F Sainfort, WP Pierskalla. Kluwer Academic Publishers, Hillier International Series in OR/MS. 2004.
  • M Zaider, EK Lee, Treatment planning for low dose rate and high dose rate brachytherapy. In Basic and Advanced Techniques in Prostate Brachytherapy, Chapter 12. Editors: A Dicker, GS Merrick, LG Gomella, RK Valicenti, F Waterman, Gomella. 1-84184-298-2, CRC Press, 2004.
  • EK Lee, Branch-and-bound methods. In Handbook of Applied Optimization, Chapter 3, Section 2. Editors: Mauricio G. C. Resende and Panos M. Pardalos. Oxford University Press 2001, ISBN 0-19-512594-0.
  • EK Lee, J Mitchell, Branch-and-bound methods for integer programming. In Encyclopedia of Optimization, Volume II, 509-519. Editors: Chris A. Floudas, and Panos M. Pardalos. Kluwer Academic Publishers, The Netherlands 2001.
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Courses

  • Spring 1996. (Columbia) IEOR 6608 Integer Programming
  • Spring 1997. (Columbia) IEOR 4600 Applied Integer Programming
  • Spring 1997. (Columbia) IEOR 4004 Introduction to Operations Research -- Deterministic Models
  • Fall 1997. ISyE 3231 Deterministic Operations Research
  • Winter 1998. ISyE 6662 Optimization II -- Part II:Integer Programming
  • Fall 1998. ISyE 3231 Deterministic Operations Research
  • Spring 2000 ISyE 4803 Topics in Optimization -- Applications to Real-World Problems
  • Spring 2001 ISyE 4104 Senior Design
  • Spring 2002. ISyE 6662 Optimization II
  • Fall 2002. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
  • Spring 2003. ISyE 4231 Engineering Optimization (Section B)
  • Fall 2003. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
  • Spring 2004. ISyE 4231 Engineering Optimization (Section C)
  • Fall 2004. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2004. BIOL 8802 Topics in Bioinformatics -- Lectures on Cancer Bioinformatics and Predictive Models in Disease Diagnosis
  • Spring 2005. ISyE 4231 Engineering Optimization (Section C)
  • Fall 2005. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2006. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2006. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2007. ISyE 3133 Engineering Optimization (Section B)
  • Spring 2007. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2007. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2008. ISyE 6679 Computational Methods
  • Spring 2008. ISyE 4601 Senior Design
  • Spring 2008 (Emory). BIOS 509 Biomedical Informatics in Clinical Research
  • Fall 2008. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2009. ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2009. BIOL 8803/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Predictive Modeling

Hobbies

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