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- Mathematical theory and modeling - complex/systems modeling, optimization and logistics theory, machine learning and predictive algorithms, decision theory and risk analysis.
- High-performance computing - information technology, software enterprise design for industrial, biomedicine, and healthcare applications.
- Large-scale optimization - linear/nonlinear mixed integer programming, combinatorial optimization, parallel algorithms.
- Biomedicine and clinical research - biomedical modeling, informatics and algorithmic strategies for genomic analysis, health risk prediction, early disease prediction and diagnosis, optimal treatment strategies and drug delivery, healthcare outcome analysis and treatment prediction.
- Healthcare policy, management, and decision analysis - systems modeling, quality improvement, operations efficiency, organizational transformation.
- Public health and medical preparedness - emergency response, large-scale dispensing, disease propagation analysis, and economic impact.
- Homeland security and defense - surveillance and detection, biodefense, radiological emergency preparedness, medical countermeasures, large-scale response and disaster relief logistics, population protection, design of resilient critical infrastructure.
- Industrial applications - efficiency and quality of services; portfolio optimization, organizational transformation
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M Artzrouni, CB Begg, R Chabiniok, J Clairambault, AJE Foss, J Hargrove6, EK Lee, JH Siggers, M Tindall, The role and impact of mathematics in medicine: A collective account. American Journal of Translational Research, 3(5):492-497, 2011.
CD. Corley, R Arthur, RT Brigantic, C Bruckner-Lea, G Calapristi, JS Chung, G Dowling, D Hartley, S Kennedy, A Kircher, S Klucking, MJ Lancaster, T McKenzie, EK Lee, N Nelson, J Olsen, C Pancerella, T Quitugua, JT Reed, C Thomas, R Walters, Assessing the continuum of event-based biosurveillance through an operational lens. Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science. Accepted 2011. Appeared online Feb 9 2012.
BT Denton, G Alagoz, A Holder, EK Lee, Medical decision making: open research challenges. IIE Transactions on Healthcare Engineering. Accepted 2011.
IOM (Institute of Medicine) and NRC (National Research Council). 2011. BioWatch and Public Health Surveillance: Evaluating Systems for the Early Detection of Biological Threats. Abbreviated Version. Washington, DC: The National Academies Press. (The unabbreviated version is classified.)
EK Lee, A
Mejia, Senior, Jose, Improving patient safety through medical alert management:
an automated decision tool to reduce alert fatigue. American Medical Informatics
Association 2010 Symposium Proceedings, 417-421, 2010.
JJ , DA Hirsh, EK Lee, R Massey, B Weselman, HK Simon, Practice characteristics that influence nonurgent pediatric emergency department utilization. Academic Pediatrics, 10(1): 70-74, 2010.
S Guerlain, EK Lee, Engineering the healthcare delivery system. Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2009 Symposium (2010). National Academy of Engineering (NAE) (selected by NAE to organize and lead the "Engineering the Healthcare Delivery System" cluster)
EK Lee, CH Chen, F Pietz, B Benecke, Modeling and optimizing the public health infrastructure for emergency response. Interfaces -- 2008 Wagner Prize Special Issue, 39(5):476-490, 2009
EK Lee, HK Smalley, Y Zhang, F Pietz, B Benecke. Facility location and multi-modality mass dispensing strategies and emergency response for biodefense and infectious disease outbreaks. International Journal on Risk Assessment and Management -- Biosecurity Assurance in a Threatening World: Challenges, Explorations, and Breakthroughs, 12(2/3/4):311-351, 2009.
EK Lee, Mixed integer programming approach for cancer therapeutics. Paper for the 2009 National Science Foundation (NSF) Civil, Mechanical and Manufacturing Innovation Engineering Research and Innovation Conference. 1-9. Honolulu, Jun 2009.
EK Lee, M Zaider, Operations research advances cancer therapeutics. Interfaces -- 2007 Franz Edelman Prize Special Issue, 38(1):5-25, 2008.
A Jayashankar, U Udayasankar, S Sebastian, M Kalra, EK Lee, W Small, MDCT of Thoraco-Abdominal Trauma: An Evaluation of the Success and Limitations of Primary Interpretation Using Multiplanar Reformatted Images versus Axial Images. Emergency Radiology, 15(1):29-34, 2008.
PK Mehta, L Simpson, EK Lee, TA Lyle, ME McConnell, WM Book, Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. Texas Heart Institute Journal, 35(3):256-261, 2008.
EK Lee, Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering -- Systems Biology, Bioinformatics, and Computational Biology, 35(6):1095-1109, 2007.
EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Data Mining, Systems Analysis, and Optimization in Biomedicine. Editors: O Seref, OE Kundakcioglu and P Pardalos. AIP Conference Proceedings, 953:1-42, 2007.
EK Lee, Optimization-Based Predictive Models in Medicine and Biology. Optimization in Medicine, Springer Netherlands, Springer Series in Optimization and Its Application, 12: 127-151, 2007.
EK Lee, KD Cha, JO Deasy, Robust optimization to accommodate effects of systematic treatment uncertainties. In Proceedings for International Conference on The Use of Computers in Radiation Therapy, 6256:1-5, 2007.
EK Lee, KD Cha, T Bortfeld, JO Deasy, 4D-Image-Guided treatment planning optimization for managing organ motion in radiotherapy planning. Proceedings for International Conference on The Use of Computers in Radiation Therapy, 6205:1-5, 2007.
EK Lee, T Easton, K Gupta, Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research, Operations Research in Medicine -- Computing and Optimization in Medicine and Life Sciences, 148: 167-187, 2006.
EK
Lee, S Maheshwary, J Mason, W Glisson, Large-scale dispensing for emergency
response to bioterrorism & infectious disease outbreak. Interfaces -- OR
Applications for Homeland Defense, 36(6): 591-607, 2006.
EK Lee, T Fox, I Crocker, Simultaneous beam geometry and intensity map optimization in intensity-modulated radiation therapy. International Journal of Radiation Oncology, Biology and Physics, 64(1): 301-320, 2006.
EK Lee, JO Deasy, Optimization in intensity-modulated radiation therapy. SIAG/OPT Views-and-News, Optimization in Medicine, 17(2): 20-32, 2006.
J Deasy, EK Lee, T Bortfeld, M Langer, K Zakarian, J Alaly, Y Zhang, H Liu, R Mohan, R Ahuja, A Pollack, J Purdy, R Rardin, A collaboratory for radiation therapy treatment planning optimization research, Annals of Operations Research, Operations Research in Medicine -- Computing and Optimization in Medicine and Life Sciences, 148: 55-63, 2006.
EK Lee, S
Maheshwary, J Mason,
Decision support system for mass dispensing of medications for infectious disease outbreaks and bioterrorist attacks. Annals of Operations Research, Computing and
Optimization in Medicine and Life Sciences, 148: 25-53, 2006.
EK Lee, S
Maheshwary, J Mason, Emergency treatment response and real-time staff allocation
for bioterrorism and infectious disease outbreak. The INFORMS William Pierskalla
Best Paper Award on research excellence in HealthCare and Management Science,
Nov 2005.
L Simpson, EK Lee, BJ Hott, DJ Vega and WM Book, Long-term results of angioplasty versus stenting in cardiac transplant recipients with allograft vasculopathy.
The Journal of Heart and Lung Transplantation, 24(9): 1211-1217, 2005.
L Simpson, PK Mehta, BJ Hott, JD Vega, EK Lee and WM Book, Long term results of angioplasty versus stenting in cardiac transplant recipients with allograft vasculopathy, International society for heart and lung transplantation (ISHLT), 2004.
EK Lee, M Zaider, Intraoperative Dynamic Dose Optimization in Permanent Prostate Implants. International Journal of Radiation Oncology, Biology and Physics, 56(3):854-861, 2003.
EK Lee, J Deasy, M Langer, R Rardin, J Deye, F Mahoney, Final report -- NCI/NSF workshop on operations research applied to radiation therapy, Washington, DC, February 7-9, 2002. Annals of Operations Research -- Optimization in Medicine, 119:143-146, 2003.
EK Lee, T Fox, I Crocker, Integer programming applied to Intensity-modulated radiation therapy treatment planning. Annals of Operations Research -- Optimization in Medicine, 119:165-181, 2003.
EK Lee, M Zaider, Mixed Integer Programming Approaches to Treatment Planning for Brachytherapy -- Application to Permanent Prostate Implants.
Annals of Operations Research -- Optimization in Medicine, 119: 147-163, 2003.
JC Landry, M Koshy, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis, Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction. Proceedings of American Society of Clinical Oncology, 22: 297, 2003.
M Langer, EK Lee, JO Deasy, R Rardin, J Deye, Operations research applied to radiotherapy, an NCI-NSF - sponsored workshop February 7-9, 2002. International Journal of Radiation Oncology, Biology, Physics, 57(3):762-768, 2003.
EK Lee, AYC Fung, JP Brooks, M Zaider, Automated planning volume definition in soft-tissue sarcoma adjuvant brachytherapy, Physics in Medicine and Biology, 47(11):1891-1910, 2002.
EK Lee, M Zaider,
On the Determination of an Effective Planning Volume for Permanent Prostate Implants. International Journal of Radiation Oncology, Biology and Physics, 49(4):1197-1206, 2001
EK Lee, T Fox, I Crocker, Optimization of Radiosurgery Treatment Planning via Mixed Integer Programming. Medical Physics, 27(5):995-1004, 2000.
M Zaider, M Zelefsky, EK Lee, K Zakian, HA Amols, J Dyke, J Koutcher, Treatment Planning for Prostate Implants Using MR Spectroscopy Imaging. International Journal of Radiation Oncology, Biology and Physics, 47(4):1085-96, 2000. (secondary link)
CS Wuu, RD Ennis, PB Schiff, EK Lee, M Zaider, Dosimetric and Volumetric Criteria for Selecting a Source Activity and a Source Type I-125 or Pd-103 and Source Activity in the Presence of Irregular Seed Placement in Permanent Prostate Implants. International Journal of Radiation Oncology, Biology and Physics, 47: 815-820, 2000.
EK Lee, RJ Gallagher, M Zaider, Planning implants of radionuclides for the treatment of prostate cancer: an application of mixed integer programming.
Optima (Mathematical Programming Society Newsletter), feature article, 61: 1-10, 1999.
EK Lee, RJ Gallagher, D Silvern, CS Wuu, M Zaider, Treatment Planning for Brachytherapy: An Integer Programming Model, Two Computational Approaches and Experiments with Permanent Prostate Implant Planning. Physics in Medicine and Biology, 44(1):145-165, 1999.
EK Lee, D Silvern, R Gallagher, LG Stabile, RD Ennis, CR Moorthy, M Zaider, Treatment planning for permanent prostate implants: genetic algorithm versus integer programming. Medical & Biological Engineering & Computing 35: Supplement Part 2, 1997.
RJ Gallagher, EK Lee, Mixed Integer Programming Optimization Models for Brachytherapy Treatment Planning. In: Daniel R. Masys, Ed. Proceedings of the 1997 American Medical Informatics Association Annual Fall Symposium, 278-282, 1997.
< List of Selected Papers >
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BIOMEDICAL INFORMATICS, PREDICTIVE MODELS, EARLY DIAGNOSIS, OUTCOME
PREDICTION
HI Nakaya, J Wrammert, EK Lee, et al, Systems biology of vaccination for seasonal influenza in humans. Nature Immunology, 12: 786-795, 2011.
EK Lee, HR Lee, A Quarshie, SEACOIN -- An investigative tool for biomedical informatics researchers. American Medical Informatics Association Annual Symposium Processdings, 750-759, 2011.
EK Lee, A
Mejia, Senior, Jose, Improving patient safety through medical alert management:
an automated decision tool to reduce alert fatigue. American Medical Informatics
Association Annual Symposium Proceedings, 417-421. 2010.
EK Lee, CH Chen, F Pietz, B Benecke, Disease propagation analysis and mitigation strategies for effective mass dispensing. American Medical Informatics Association Annual Symposium Proceedings, 427-431. 2010.
M Hagen, EK Lee, BIOSPIDA: A relational database translator for NCBI. American Medical Informatics Association Annual Symposium Proceedings, 422-426,
2010
EK Lee, K Cha, Automated data collection and integration for cancer treatment design and clinical quality evaluation investigations. 2010 AMIA Summit on Clinical Research Informatics, San Francisco, CA, Mar 2010.
JP Brooks, EK Lee, Analysis of the consistency of a mixed integer programming-based multi-category constrained discriminant model, Annals of Operations Research on Data Mining, 174(1): 147-168, 2010.
MT McCabe, EK Lee, PM Vertino, A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation. Cancer Research, 69(1):282-291, 2009.
TD Querec, R Akondy, EK Lee, W Cao, HI Nakaya, D Teuwen, A Pirani, K Gernert, J Deng, B Marzolf, K Kennedy, H Wu, S Bennouna, H Olouch, J Miller, RZ Vencio, M Mulligan, A Aderem, R Ahmed, B Pulendran, Systems biology approach predicts the immunogenicity of the yellow fever vaccine in humans. Nature Immunology, 10:116-125, 2009.
EK Lee, Machine learning framework for classification in medicine and biology. Integration of AI and OR Techniques in Constraint Programming for Combinatorial Optimization Problems, 6th International Conference, CPAIOR 2009, Proceedings. WJ van Hoeve, JN Hooker (Eds). Lecture Notes in Computer Science, 5547:1-7, Springer 2009. (plenary speaker)
Q Ling, C Pu, EK Lee, A model-driven approach to manage clinical and translational data in relational databases. IEEE Bioinformatics and Biomedicine, Workshop on Biomedical and Health Informatics. 2008.
EK Lee, Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering -- Systems Biology, Bioinformatics, and Computational Biology, 35(6):1095-1109, 2007.
EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Data Mining, Systems Analysis, and Optimization in Biomedicine. Editors: O Seref, OE Kundakcioglu and P Pardalos. AIP Conference Proceedings, 953:1-42, 2007.
EK Lee, Optimization-Based Predictive Models in Medicine and Biology. Optimization in Medicine, Springer Netherlands, Springer Series in Optimization and Its Application, 12: 127-151, 2007.
EK Lee, T Easton, K Gupta, Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research, Operations Research in Medicine -- Computing and Optimization in Medicine and Life Sciences, 148: 167-187, 2006.
FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, DNA motifs associated with aberrant CpG island methylation. Genomics, 87:572-579, 2006.
EK Lee, RJ Gallagher, A Campbell, M Prausnitz, Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra. IEEE Transactions on Biomedical Engineering, 51(1): 82-89, 2004.
FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, Predicting Aberrant CpG Island Methylation, Dec 2002. Proceedings of the National Academy of Science, 100(21):12253-12258, 2003.
EK Lee, RJ Gallagher, D. Patterson, A Linear Programming Approach to Discriminant Analysis with a Reserved Judgment Region, INFORMS Journal on Computing, 15(1):23-41, 2003.
RJ Gallagher, EK Lee, D Patterson, Constrained Discriminant Analysis via 0/1 Mixed Integer Programming. Annals of Operations Research, Special Issue on
Non-Traditional Approaches to Statistical Classification and Regression, 74, 65-88, 1997.
RJ Gallagher, EK Lee, D Patterson, An Optimization Model for Constrained Discriminant Analysis and Numerical Experiments with Iris, Thyroid, and
Heart Disease Datasets In: Cimino JJ, Ed. Proceedings of the 1996 American Medical Informatics Association Annual Fall Symposium, 209-213, 1996.
EK Lee, RJ Gallagher, Mixed integer programming models for machine learning and discriminant analysis, Proceedings of ICIAM, 1995.
< List of Selected Papers >
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LARGE-SCALE OPTIMIZATION (THEORY AND COMPUTATION) AND LOGISTICS
EK Lee, CH Chen, F Pietz, B Benecke, Disease propagation analysis and mitigation strategies for effective mass dispensing. American Medical Informatics Association Annual Symposium Proceedings, 427-431, 2010.
JP Brooks, EK Lee, Analysis of the consistency of a mixed integer programming-based multi-category constrained discriminant model, Annals of Operations Research on Data Mining, 174(1): 147-168, 2010.
EK Lee, CH Chen, F Pietz, B Benecke, Modeling and optimizing the public health infrastructure for emergency response. Interfaces -- 2008 Wagner Prize Special Issue, 39(5): 476-490, 2009.
EK Lee, HK Smalley, Y Zhang, F Pietz, B Benecke. Facility location and multi-modality mass dispensing strategies and emergency response for biodefense and infectious disease outbreaks. International Journal on Risk Assessment and Management -- Biosecurity Assurance in a Threatening World: Challenges, Explorations, and Breakthroughs, 12(2/3/4):311-351, 2009.
EK Lee, S Maheshwary, Facets of conflict hypergraphs. Annals of Operations Research -- In Memory of Peter Hammer. Submitted.
EK Lee, Modeling and optimization the public health infrastructure for emergency response. Modeling and Simulation for Emergency Management and Health Care Systems: Workshop Summary. US Department of Commerce and National Institutes of Standards and Technology, 2008.
EK Lee, M Zaider, Operations Research Advances Cancer Therapeutics. Interfaces -- 2007 Franz Edelman Prize Special Issue, 38(1):5-25, 2008.
JP Brooks, EK Lee, Solving a mixed integer programming multi-category classification model with misclassification constraints. INFORMS Journal on Computing. Submitted 2007.
EK Lee, Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering -- Systems Biology, Bioinformatics, and Computational Biology, 35(6):1095-1109, 2007.
EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Data Mining, Systems Analysis, and Optimization in Biomedicine. Editors: O Seref, OE Kundakcioglu and P Pardalos. AIP Conference Proceedings, 953:1-42, 2007.
EK Lee, Optimization-Based Predictive Models in Medicine and Biology. Optimization in Medicine, Springer Netherlands, Springer Series in Optimization and Its Application, 12: 127-151, 2007.
JP Brooks and EK Lee, Mixed integer programming constrained discrimination model for credit screening. In Proceedings of the 2007 Spring Simulation Multiconference, Business and Industry Symposium, 1-6, Norfolk, VA, Mar 2007. ACM Digital Library.
JP Brooks and EK Lee, Solving a mixed-integer programming formulation of a multi-category constrained discrimination model. In Proceedings of the 2006 INFORMS Workshop on Artificial Intelligence and Data Mining, 1-6, Pittsburgh, PA, November 2006.
EK Lee, S Maheshwary, J Mason, W Glisson, Large-scale dispensing for emergency response to bioterrorism & infectious disease outbreak. Interfaces -- OR Applications for Homeland Defense, 36(6): 591-607, 2006.
EK Lee, S Maheshwary, J Mason, Emergency response decision support system for infectious disease outbreak and biodefense. Annals of Operations Research, Computing and Optimization in Medicine and Life Sciences, 148: 25-53, 2006.
JCC Tsai, VCP Chen, EK Lee, EL Johnson, Parallelization of the MARS value function approximation in a decision-making framework for wastewater treatment. Computational Statistics and Data Analysis 2005.(secondary link)
EK Lee, Generating cutting planes for mixed integer programming problems in a parallel computing environment. INFORMS Journal on Computing 16(1):3-26, 2004.
T Easton, K Hooker, EK Lee, Facets of the independent set polytope. Mathematical Programming B, 98: 177-199, 2003.
Bartholdi, J. J., III, D. Dave, EK. Lee, Computing optimal load plans in less-than-truckload freight networks. Advances in Manufacturing, Logistics, and Supply Chain Management: Proceedings of the International Workshop in IT-Enabled Manufacturing, Logistics, and Supply Chain Management, Bangalore, India, 1-22, 2003.
EK Lee, RJ Gallagher, D. Patterson, A Linear Programming Approach to Discriminant Analysis with a Reserved Judgment Region, INFORMS Journal on Computing, 15(1):23-41, 2003.
EK Lee, J Linderoth, M Savelsbergh, A parallel linear programming-based heuristic for large-scale set partitioning problems. INFORMS Journal on Computing, 13: 191-209, 2001.
EK Lee, A linear-programming based parallel cutting plane algorithm for mixed integer programming problems. Proceeding for the Third Scandinavian Workshop on Linear Programming 22-31, 1999.
RE Bixby, W Cook, A Cox, EK Lee, Computational experience with parallel mixed integer programming in a Distributed Environment. Annals of Operations Research -- Parallel Optimization, 90: 19-43, 1999.
EK Lee, J Mitchell, Computational experience of an interior-point SQP algorithm in a parallel branch-and-bound framework. High Performance Optimization Techniques, Franks, Roos, Terlaky, Zhang (Eds), Kluwer Academic Publishers, 329-347, 1997.
EK Lee, J Mitchell, Computational experience of an interior-point algorithm in a parallel branch-and-cut framework. Proceedings for SIAM Conference on Parallel Processing for Scientific Computing, 1-9, 1997.
M Junger, EK Lee, P Mutzel, T Odenthal, A polyhedral approach to the multi-layer crossing minimization problem. Graph Drawing, Lecture Notes in Computer Science, Springer-Verlag, LNCS Vol. 1353: 13-24, 1997.
RJ Gallagher, EK Lee, D Patterson, Constrained Discriminant Analysis via 0/1 Mixed Integer Programming. Annals of Operations Research, Special Issue on Non-Traditional Approaches to Statistical Classification and Regression, 74, 65-88, 1997.
EK Lee, On facets of knapsack equality polytopes, Journal of Optimization Theory and Applications 94(1): 223-239, July 1997.
EK Lee, J Mitchell, Computational experience in nonlinear mixed integer programming. The Operations Research Proceedings, Springer, 95-100, 1996.
RE Bixby, EK Lee, Solving a truck dispatching scheduling problem using branch-and-cut, Operations Research, 46(3): 355-367, 1994.
< List of Selected Papers >
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REVIEWED BIOLOGICAL / MEDICAL ABSTRACTS
EK Lee, F Yuan, A Templeton, R Yao, JC Chu, PET-Image guided dose escalation in high-dose rate radiation therapy. International Journal of Radiation Oncology Biology Physics, 78(3): S415, 2010.
EK Lee, KD Cha, JO Deasy and C Hamilton, Handling multiple clinical objectives in intensity modulated radiation therapy treatment planning. Medical Physics, 37 (6): 3214, 2010.
J Zhou, J Turian, EK Lee, A Templeton, Y Liao, J Chu, A Novel Approach to Tracking Intrafraction Prostate Motion during Volumetric Modulated Arc Therapy with Tomosynthesis, Medical Physics, 37: 3386, 2010.
EK Lee, K Cha. An Image-Guided Adaptive Treatment Planning Optimization for IMRT, Medical Physics, 36: 2538, 2009.
EK Lee, KD Cha, and M Zaider, Automated Planning Volume Definition for HDR Brachytherapy: Application to Intraluminal Treatment of the Bile Duct. Medical Physics, 36(6) 2530, 2009.
M McCabe, EK Lee, P Vertino, Multi-factorial prediction of aberrant CpG island methylation in cancer. AACR Special Conference Cancer Epigenetics (Boston, MA), A73, 2008.
EK Lee, K Cha, T Bortfeld, J Deasy, Robust Optimization to Accommodate Effects of Systematic Treatment Uncertainties, Medical Physics, 34: 2523, 2007.
M McCabe, EK Lee, P Vertino, Predicting methylation-prone CpG islands in human cancer. Proc. Amer. Assn. Cancer Res. 48:Abs 2839, 2007.
M McCabe, EK Lee, P Vertino, Multi-Factorial prediction of aberrant CpG island methylation in Cancer, The Sixth Georgia Tech - Oak Ridge International Conference on Bioinformatics -- In silico Biology: Gene Discovery and Systems Genomics, 35, 2007.
EK Lee, KD Cha, JO Deasy, Robust optimization to accommodate effects of systematic treatment uncertainties. In Proceedings for International Conference on The Use of Computers in Radiation Therapy, 6256:1-5, 2007.
EK Lee, KD Cha, T Bortfeld, JO Deasy, 4D-Image-Guided treatment planning optimization for managing organ motion in radiotherapy planning. Proceedings for International Conference on The Use of Computers in Radiation Therapy, 6205:1-5, 2007.
EK Lee, Large-scale pattern recognition and classification approaches for disease diagnosis, Biomedical Engineering Systems Biology and Bioinformatics, 2006.
EK Lee, M Zaider, Incorporating biological metabolite information within treatment of prostate carcinoma and analysis of dose escalation effect. International Journal of Radiation Oncology Biology Physics 66(3): Supplement 1, S572-S573, 2006.
EK Lee, KD Cha, T Bortfeld, JO Deasy, 4D Image-guided Treatment Planning Optimization for Managing Respiratory Effect in Radiotherapy Planning. Medical Physics, 33(6): 2190, 2006.
EK Lee, DP Lewis, KD Cha, Fast Generation of Integer-Valued Beam Profiles for Intensity Modulated Radiation Therapy, Medical Physics, 33: 2096, 2006.
EK Lee, D Lewis, K Cha, Efficient IMRT Delivery -- Fast Generation of Integer‐Valued Beam Profiles, Medical Physics, 33: 2096, 2006.
P Mehta, L Simpson, EK Lee, T Lyle, W Book, Endothelin-Receptor Antagonists Improve Exercise Tolerance and Oxygen Saturations in Adults with the Eisenmenger Syndrome. American Heart Association Scientific Sessions 3190, Nov 2005.
EK Lee, T Easton, K Gupta, Novel Evolutionary Models and Applications to the Sequence Alignment Problems. The Fifth Georgia Tech - Oak Ridge International Conference on Bioinformatics -- Computational Genomics and Evolutionary Biology, 63, Nov 2005.
EK Lee, FA Feltus, JF Costello, C Plass, PM Vertino, Large-Scale Genomic Pattern Recognition and Classification of Aberrantly Hypermethylated CpG Island Loci in Human Cancer. The Fifth Georgia Tech - Oak Ridge International Conference on Bioinformatics -- Computational Genomics and Evolutionary Biology, 62, Nov 2005.
FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, DNA Patterns Associated With CpG Island Methylation State. The Fifth Georgia Tech - Oak Ridge International Conference on Bioinformatics -- Computational Genomics and Evolutionary Biology, 50, Nov 2005.
EK Lee, K Cha, T Bortfeld, JO Deasy, Multistage Treatment Planning Optimization for Managing Organ Motion in Radiotherapy Planning. International Journal of Radiation Oncology Biology Physics 63 (Supplement 1: Proceedings of the 47th Annual ASTRO Meeting): S209-S210, 2005.
EK Lee, K Cha, T Bortfeld, JO Deasy, Multistage Treatment Planning Optimization for Managing Organ Motion in Radiotherapy Planning. Medical Physics, 32(6): 1925, 2005.
EK Lee, T Bortfeld, JO Deasy, Robust Optimization Including Effects of Systematic Treatment Errors. Medical Physics, 32(6): 1978, 2005.
EK Lee, D Lewis, Fast Integer-Valued Smoothing of Beam Profiles in Intensity Modulated Radiation Therapy. Medical Physics, 32(6): 1974, 2005.
EK Lee, M Zaider, Incorporating Biological Metabolite Information Within Treatment of Prostate Carcinoma. International Journal of Radiation Oncology, Biology and Physics, 60(1): S370-371, ASTRO 2004.
EK Lee, KD Cha, J Shi, Automated Data Collection and Integration for Cancer Treatment Design and Clinical Quality Evaluation Investigation. Joint BECON/BISTIC 2004 Symposium Biomedical Informatics for Clinical Decision Support: A Vision for the 21st Century, NIH Bethesda, p23 Jun 2004.
EK Lee, Optimization Techniques and Their Suitability and Robustness for IMRT Planning, invited presentation at 46th American Association of Physicists in Medicine Annual Meeting Pittsburgh 2004. Medical Physics, 31(6): 1762, 2004.
EK Lee, Handling Multiple Clinical Objectives in Intensity Modulated Radiation Therapy Treatment Planning, abstract selected for oral presentation at 46th American Association of Physicists in Medicine Annual Meeting Pittsburgh 2004. Medical Physics, 31(6): 1777, 2004.
J Deasy, EK Lee, M Langer, T Bortfeld, Y Zhang, H Liu, R Mohan, R Ahuja, J Dempsey, A Pollack, J Rosenman, A Eisbruch, R Rardin, J Purdy, C Zakarian, J Alaly, An IMRT Treatment Planning Research Collaboratory, abstract selected for oral presentation at 46th American Association of Physicists in Medicine Annual Meeting Pittsburgh 2004. Medical Physics, 31(6): 1775, 2004.
M Koshy, JC Landry , JD Lawson, N Esiashvili, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis, Potential For Toxicity Reduction Using Intensity Modulated Radiation Therapy (IMRT) For Retroperitoneal Sarcoma, accepted for presentation at ASTRO Utah 2003. International Journal of Radiation Oncology, Biology, Physics, 57(2 Suppl):S448-9, ASTRO 2003.
JC Landry, M Koshy, JD Lawson, N Esiashvili, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis, Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction, Proceedings of American Society of Clinical Oncology, 22: 297, 2003.
EK Lee, T Fox, I Crocker, Beam Geometry and Intensity Map Optimization in IMRT via Computational Optimization, abstract selected for oral presentation at AAPM San Diego July 2003. 30(6): 1385-1386, 2003.
EK Lee, JO Deasy, I El Naqa, I Kawrakow, M Vicic, Integrating a Monte Carlo Based Optimization Module Into CERR for Designing IMRT Plans, abstract selected for presentation at AAPM San Diego July 2003. Medical Physics, 30(6): 1324, 2003.
EK Lee, R Wagman, M Zaider, Treatment planning with automated planning volume definition for HDR brachytherapy -- Application to intraluminal treatment of the bile duct. International Conference on Translational Research and Pre-Clinical Strategies in Clinical Radio-Oncology'' ICTR 2003 Advances In Translational Radiation Oncology: From Molecular Signalling to Cancer Cure, March 2003.
EK Lee, M Zaider, Intra-Operative Dynamic Dose Optimization in Permanent Prostate Implants. International Conference on Translational Research and Pre-Clinical Strategies in Clinical Radio-Oncology'' ICTR 2003 Advances In Translational Radiation Oncology: From Molecular Signalling to Cancer Cure, March 2003.
FA Feltus, JF Costello, C Plass, EK Lee, PM Vertino, Identifying sequence patterns associated with aberrant CpG island methylation. Proceedings of American Association of Cancer Research LB:3. 2002.
EK Lee, M Zaider, Intra-Operative Dynamic Dose Optimization for Prostate Permanent Implants. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics, 29(6): 1228, 2002.
EK Lee, T Fox, I Crocker, Mixed Integer Programming Techniques Applied to IMRT Treatment Planning Optimization. 44th American Association of Physicists
in Medicine Annual Meeting. Medical Physics, 29(6): 1259, 2002.
JO Deasy, EK Lee, I Kawrakow, C Zakarian, A Prototype Monte Carlo-Based IMRT Treatment Planning Research System. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics, 29(6): 1254, 2002.
EK Lee, K Godette, C Anderson, J Keller, Effect of Race and Radiation Treatment Modalities on Biochemical Failure in Prostate Cancer Cases. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics, 29(6) Supplement, 2002.
EK Lee, AY Fung, M Zaider, Automated planning volume contouring in soft-tissue sarcoma adjuvant brachytherapy treatment. International Journal of Radiation Oncology, Biology, Physics, 51:3 (ASTRO 2001): 391.
EK Lee, T Fox, I Crocker, Computational Optimization for Brain Tumor Radiosurgery Treatment Planning. 43rd American Association of Physicists in Medicine Annual Meeting. Medical Physics, 28(6): 1304, 2001.
EK Lee, An Innovative Computerized Treatment Planning System for Permanent Prostate Implants. The American Association for the Advancement of Science 2001 Annual Meeting & Science Innovation Exposition, A41, February 2001. (Invited presentation with media briefings.)
EK Lee, M Zaider, IntraOperative Iterative Treatment-Plan Optimization for Prostate Permanent Implants. 2nd International Innovative Solutions
for Prostate Cancer Care meeting, 32-33, 2001.
M Zaider, EK Lee, MRS-guided Dose-Escalation Treatment Planning Optimization for Permanent Prostate Implants. 2nd International Innovative Solutions for Prostate Cancer Care meeting, 36, 2001.
M Zaider, EK Lee, K Zakian, HA Amols, M Zelefsky, J Dyke, J Koutcher, Intensity-modulated conformal treatment planning for prostate implants using magnetic resonance spectroscopy. International Journal of Radiation Oncology, Biology and Physics, 45(3):351, ASTRO 1999.
EK Lee, M Zaider, M Zelefsky, On the definition of effective planning volume in permanent prostate implants. International Journal of Radiation Oncology, Biology and Physics, 45(3): 261-262,ASTRO 1999.
D Silvern, EK Lee, RJ Gallagher, LG Stabile, RD Ennis, CR Moorthy, M Zaider, Treatment Planning for Permanent Prostate Implants: Genetic Algorithm versus Integer Programming. Medical & Biological Engineering & Computing, vol.35, Supplement Part 2, 1997.
RE Bixby, W Cook, A Cox, EK Lee, Parallelism in Mixed Integer Programming. Proceedings for the Center for Research on Parallel Computation Research symposium, 1994.
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PUBLISHED BOOKS
Optimization in Medicine and Biology. Editors: EK Lee, G Limo, Taylor and Francis, Auerbach Publications, 564 pages, 2008.
Computing and Optimization in Medicine and Life Sciences, Volume 2. Editors: EK Lee, A Sofer, Springer Netherlands, Computer Science Series, 270 pages, 2006.
Computing and Optimization in Medicine and Life Sciences, Volume 1. Editors: EK Lee, A Sofer, Springer Science, Kluwer Academic Publishers, 301 pages, 2003.
REFEREED PUBLISHED BOOK CHAPTERS
EK Lee, Y Yang, F Pietz, B Benecke, Public Health, Emergency Response, and Medical Preparedness I: Medical Surge. In Wiley Encyclopedia of Operations Research and Management Science. Editors: Cochran et al. 2011.
EK Lee, F Pietz, B Benecke, Public Health, Emergency Response, and Medical Preparedness II: Medical Countermeasures Dispensing and Large-scale Disaster Relief Efforts. In Wiley Encyclopedia of Operations Research and Management Science. Editors: Cochran et al. 2011.
EK Lee, T Guilford, Y Yang, F Pietz, B Benecke, Public Health, Emergency Response, and Medical Preparedness III: Communication Infrastructure. In Wiley Encyclopedia of Operations Research and Management Science. Editors: Cochran et al. 2011
EK Lee, Y Yang, F Pietz, B Benecke, Public Health, Emergency Response, and Medical Preparedness IV: Emergency Evacuation. In Wiley Encyclopedia of Operations Research and Management Science. Editors: Cochran et al. 2011
EK Lee, Y Yang, F Pietz, B Benecke, Public Health and Medical Preparedness. In Editor: Yuehwern Yih. CRC Press, Taylor & Francis. 2010.
EK Lee, K Gupta, Algorithms for genomics analysis. In Encyclopedia of Optimization, 2nd edition. Editors: CA Floudas, and PM Pardalos. Springer, The Netherlands 2009. ISBN: 978-0-387-74760- 6.
EK Lee, TL Wu, Disease diagnosis: optimization based methods. In Encyclopedia of Optimization, 2nd edition. Editors: CA Floudas, and PM Pardalos. Springer, The Netherlands 2009. ISBN: 978-0-387-74760-6.
EK Lee, J Mitchell, Integer programming: branch-and-bound methods. In Encyclopedia of Optimization, 2nd edition. Editors: CA Floudas, and PM Pardalos. Springer, The Netherlands 2009. ISBN: 978-0-387-74760-6.
EK Lee, TLWu, Classification and disease prediction via mathematical programming. In Handbook in Optimization in Medicine, Chapter 12. Springer Optimization and Its Application, Vol 26. Editors: PM Pardalos and HE Romeijn. 2009. ISBN: 978-0-387-09769-5.
EK Lee, K Gupta, Algorithms for genomics analysis. In Handbook in Optimization in Medicine, Chapter 9. Springer Optimization and Its Application, Vol 26. Editors: PM Pardalos and HE Romeijn. 2009. ISBN: 978-0-387-09769-5.
EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Optimization in Medicine and Biology, Chapter 1, 3-60. Editors: EK Lee, G Lim, Taylor and Francis, Auerbach Publications, 2008.
EK Lee, K Gupta, Algorithms for genomics analysis. In Optimization in Medicine and Biology, Chapter 12, 355-393. Editors: EK Lee, G Limo, Taylor and Francis, Auerbach Publications, 2008.
EK Lee, D Lewis, Integer programming for telecommunications. In Handbook of Optimization in Telecommunications, Chapter 3, 67-102. Editors: GC Resende and PM Pardalos. Kluwer Academic Publishers, 2005.
EK Lee, M Zaider, Optimization and decision support in brachytherapy treatment planning. In Operations Research and Health Care: A Handbook of Methods and Applications, Chapter 28. (International Series in Operations Research & Management Science) Editors: M Bandeau, F Sainfort, WP Pierskalla. Kluwer Academic Publishers, Hillier International Series in OR/MS. 2004.
M Zaider, EK Lee, Treatment planning for low dose rate and high dose rate brachytherapy. In Basic and Advanced Techniques in Prostate Brachytherapy, Chapter 12. Editors: A Dicker, GS Merrick, LG Gomella, RK Valicenti, F Waterman, Gomella. 1-84184-298-2, CRC Press, 2004.
EK Lee, Branch-and-bound methods. In Handbook of Applied Optimization, Chapter 3, Section 2. Editors: Mauricio G. C. Resende and Panos M. Pardalos. Oxford University Press 2001, ISBN 0-19-512594-0. Honorable mention by the Association of American Publishers' Outstanding Professional and Scholarly
Titles of 2002 in Computer Science.
EK Lee, J Mitchell, Branch-and-bound methods for integer programming. In Encyclopedia of Optimization, Volume II, 509-519. Editors: Chris A. Floudas, and Panos M. Pardalos. Kluwer Academic Publishers, The Netherlands 2001.
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Spring 1996. (Columbia) IEOR 6608 Integer Programming
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Spring 1997. (Columbia) IEOR 4600 Applied Integer Programming
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Spring 1997. (Columbia) IEOR 4004 Introduction to Operations Research -- Deterministic Models
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Fall 1997. ISyE 3231 Deterministic Operations Research
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Winter 1998. ISyE 6662 Optimization II -- Part II:Integer Programming
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Fall 1998. ISyE 3231 Deterministic Operations Research
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Spring 2000 ISyE 4803 Topics in Optimization -- Applications to Real-World Problems
- Spring 2001 ISyE 4104 Senior Design
- Spring 2002. ISyE 6662 Optimization II
- Fall 2002. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
- Spring 2003. ISyE 4231 Engineering Optimization (Section B)
- Fall 2003. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
- Spring 2004. ISyE 4231 Engineering Optimization (Section C)
- Fall 2004. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
- Spring 2004. BIOL 8802 Topics in Bioinformatics -- Lectures on Cancer Bioinformatics and Predictive Models in Disease Diagnosis
- Spring 2005. ISyE 4231 Engineering Optimization (Section C)
- Fall 2005. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
- Spring 2006. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
- Fall 2006. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
- Spring 2007. ISyE 3133 Engineering Optimization (Section B)
- Spring 2007. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
- Fall 2007. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
- Spring 2008. ISyE 6679 Computational Methods
- Spring 2008. ISyE 4601 Senior Design
- Spring 2008 (Emory). BIOS 509 Biomedical Informatics in Clinical Research
- Fall 2008. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics
and Large-Scale Biocomputing
- Spring 2009. ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare
- Fall 2009. BIOL 8803/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Predictive Modeling
- Spring 2010. ISyE 6679 Computational Methods
- Spring 2010. ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare
- Fall 2010. ISyE 6679 Computational Methods
- Fall 2010. BIOL 7015/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Predictive Modeling
- Spring 2011. ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare
- Fall 2011. BIOL 7015/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Predictive Modeling
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