Photo of Professor Lee

Eva K. Lee

Professor
Director, Center for Operations Research in Medicine and HealthCare
H. Milton Stewart School of Industrial and Systems Engineering
Georgia Institute of Technology
Atlanta, GA 30332-0205
Phone: (404) 894-4962
Fax: (404) 894-2301
Email: eva.lee AT gatech.edu
Co-Director, NSF I/UCRC Center for Health Organization Transformation

Distinguished Scholar in Health Systems, Health System Institute, Georgia Tech/Emory University


Personal Biosketch



Affiliations

Research Interests

  • Mathematical theory and modeling - complex/systems modeling, optimization and logistics theory, machine learning and predictive algorithms, decision theory and risk analysis.
  • High-performance computing - information technology, software enterprise design for industrial, biomedicine, and healthcare applications.
  • Large-scale optimization - linear/nonlinear mixed integer programming, combinatorial optimization, parallel algorithms.
  • Biomedicine and clinical research - biomedical modeling, informatics and algorithmic strategies for genomic analysis, health risk prediction, early disease prediction and diagnosis, optimal treatment strategies and drug delivery, healthcare outcome analysis and treatment prediction.
  • Healthcare policy, management, and decision analysis - systems modeling, quality improvement, operations efficiency, organizational transformation.
  • Public health and medical preparedness - emergency response, large-scale dispensing, disease propagation analysis, and economic impact.
  • Homeland security and defense - surveillance and detection, biodefense, radiological emergency preparedness, medical countermeasures, large-scale response and disaster relief logistics, population protection, design of resilient critical infrastructure.
  • Industrial applications - efficiency and quality of services; portfolio optimization, organizational transformation
< Top of Page >

Refereed Articles, Proceedings, and Medical Abstracts(Selected)


MEDICAL THERAPEUTICS, QUALITY DELIVERY, SYSTEMS MODELING, OPTIMIZATION, AND DECISION MAKING

M Artzrouni, CB Begg, R Chabiniok, J Clairambault, AJE Foss, J Hargrove, EK Lee, JH Siggers, M Tindall. The first international workshop on the role and impact of mathematics in medicine: A collective account. American Journal of Translational Research. 2011; 3(5):492-497.

CD Corley, MJ Lancaster, RT Brigantic, JS Chung, RA Walters, RR Arthur, CJ Bruckner-Lea, A Calapristi, G Dowling, DM Hartley, S Kennedy, A Kircher, S Klucking, EK Lee, T McKenzie, NP Nelson, J Olsen, C Pancerella, TN Quitugua, JT Reed, CS Thomas. Assessing the continuum of event-based biosurveillance through an operational lens. Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science. 2012; 10(1):131-141.

BT Denton, O Alagoz, A Holder, EK Lee. Medical decision making: open research challenges. IIE Transactions on Healthcare Systems Engineering. 2011; 1(3):161-167.

IOM (Institute of Medicine) and NRC (National Research Council). BioWatch and Public Health Surveillance: Evaluating Systems for the Early Detection of Biological Threats. Abbreviated Version. Washington, DC: The National Academies Press. 2010. (The unabbreviated version is classified.)

EK Lee, AF Mejia, T Senior, J Jose. Improving patient safety through medical alert management: An automated decision tool to reduce alert fatigue. American Medical Informatics Association 2010 Symposium Proceedings. 2010; 417-421.

JJ Sturm, DA Hirsh, EK Lee, R Massey, B Weselman, HK Simon. Practice characteristics that influence nonurgent pediatric emergency department utilization. Academic Pediatrics. 2010; 10(1):70-74.

S Guerlain, EK Lee. Engineering the health care delivery system. Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2009 Symposium. National Academy of Engineering (NAE). 2010. (Selected by NAE to organize and lead the "Engineering the Healthcare Delivery System" cluster.)

EK Lee, CH Chen, F Pietz, B Benecke. Modeling and optimizing the public-health infrastructure for emergency response. Interfaces — 2008 Wagner Prize Special Issue. 2009; 39(5):476-490.

EK Lee, HK Smalley, Y Zhang, F Pietz, B Benecke. Facility location and multi-modality mass dispensing strategies and emergency response for biodefense and infectious disease outbreaks. International Journal on Risk Assessment and Management — Biosecurity Assurance in a Threatening World: Challenges, Explorations, and Breakthroughs. 2009; 12(2/3/4):311-351.

EK Lee. Mixed integer programming approach for cancer therapeutics. Paper for the 2009 National Science Foundation (NSF) Civil, Mechanical and Manufacturing Innovation Engineering Research and Innovation Conference. Honolulu. Jun 2009; 1-9.

EK Lee, M Zaider. Operations research advances cancer therapeutics. Interfaces — 2007 Franz Edelman Prize Special Issue. 2008; 38(1):5-25.

A Jayashankar, U Udayasankar, S Sebastian, EK Lee, M Kalra, W Small. MDCT of thoraco-abdominal trauma: an evaluation of the success and limitations of primary interpretation using multiplanar reformatted images vs axial images. Emergency Radiology. 2008; 15(1):29-34.

PK Mehta, L Simpson, EK Lee, TA Lyle, ME McConnell, WM Book. Endothelin receptor antagonists improve exercise tolerance and oxygen saturations in patients with Eisenmenger syndrome and congenital heart defects. Texas Heart Institute Journal. 2008; 35(3):256-261.

EK Lee. Large-Scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering — Systems Biology, Bioinformatics, and Computational Biology. 2007; 35(6):1095-1109.

EK Lee, TL Wu. Classification and disease prediction via mathematical programming. In: O Seref, OE Kundakcioglu, PM Pardalos, eds. Data Mining, Systems Analysis and Optimization in Biomedicine. AIP Conference Proceedings. 2007; 953:1-42.

EK Lee. Optimization-based predictive models in medicine and biology. In: CJS Alves, PM Pardalos, LN Vicente, eds. Optimization in Medicine. Springer Optimization and Its Applications, Vol 12. The Netherlands: Springer; 2008:127-151.

EK Lee, K Cha, JO Deasy. Robust optimization to accommodate effects of systematic treatment uncertainties. Proceedings for International Conference on The Use of Computers in Radiation Therapy. 2007; 6256:1-5.

EK Lee, K Cha, T Bortfeld, JO Deasy. 4D-image-guided treatment planning optimization for managing organ motion in radiotherapy planning. Proceedings for International Conference on The Use of Computers in Radiation Therapy. 2007; 6205:1-5.

EK Lee, T Easton, K Gupta. Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research, Operations Research in Medicine—Computing and Optimization in Medicine and Life Sciences. 2006; 148(1):167-187.

EK Lee, S Maheshwary, J Mason, W Glisson. Large-scale dispensing for emergency response to bioterrorism and infectious-disease outbreak. Interfaces—OR Applications for Homeland Defense. 2006; 36(6):591-607.

EK Lee, T Fox, I Crocker. Simultaneous beam geometry and intensity map optimization in intensity-modulated radiation therapy. International Journal of Radiation Oncology, Biology and Physics. 2006; 64(1):301-320.

EK Lee, JO Deasy. Optimization in intensity modulated radiation therapy. SIAG/OPT Views-and-News, Optimization in Medicine. 2006; 17(2):20-32.

J Deasy, EK Lee, T Bortfeld, M Langer, K Zakarian, J Alaly, Y Zhang, H Liu, R Mohan, R Ahuja, A Pollack, J Purdy, R Rardin. A collaboratory for radiation therapy treatment planning optimization research. Annals of Operations Research, Operations Research in Medicine—Computing and Optimization in Medicine and Life Sciences. 2006; 148(1):55-63.

EK Lee, S Maheshwary, J Mason, W Glisson. Decision support system for mass dispensing of medications for infectious disease outbreaks and bioterrorist attacks. Annals of Operations Research, Operations Research in Medicine—Computing and Optimization in Medicine and Life Sciences. 2006; 148(1):25-53.

EK Lee, S Maheshwary, J Mason. Emergency treatment response and real-time staff allocation for bioterrorism and infectious disease outbreak. The INFORMS William Pierskalla Best Paper Award on research excellence in HealthCare and Management Science. Nov 2005.

L Simpson, EK Lee, BJ Hott, DJ Vega, WM Book. Long-term results of angioplasty versus stenting in cardiac transplant recipients with allograft vasculopathy. The Journal of Heart and Lung Transplantation. 2005; 24(9):1211-1217.

L Simpson, EK Lee, BJ Hott, DJ Vega, WM Book. Long-term results of angioplasty versus stenting in cardiac transplant recipients with allograft vasculopathy. The Journal of Heart and Lung Transplantation. 2005; 24(9):1211-1217.

EK Lee, M Zaider. Intraoperative dynamic dose optimization in permanent prostate implants. International Journal of Radiation Oncology, Biology and Physics. 2003; 56(3):854-861.

EK Lee, J Deasy, M Langer, R Rardin, J Deye, F Mahoney, Final report -- NCI/NSF workshop on operations research applied to radiation therapy, Washington, DC, February 7-9, 2002. Annals of Operations Research -- Optimization in Medicine, 119:143-146, 2003.

EK Lee, T Fox, I Crocker. Integer programming applied to intensity-modulated radiation therapy treatment planning. Annals of Operations Research — Computational Approaches to Medical and Life Sciences Applications. 2003; 119(1-4):165-181.

EK Lee, M Zaider. Mixed integer programming approaches to treatment planning for brachytherapy — Application to permanent prostate implants. Annals of Operations Research — Computational Approaches to Medical and Life Sciences Applications. 2003; 119(1-4):147-163.

JC Landry, M Koshy, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis. Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction. Proceedings of the American Society of Clinical Oncology. 2003; 22.

M Langer, EK Lee, JO Deasy, RL Rardin, JA Deye. Operations research applied to radiotherapy, an NCI-NSF—sponsored workshop February 7-9, 2002. International Journal of Radiation Oncology, Biology and Physics. 2003; 57(3):762-768.

EK Lee, AYC Fung, JP Brooks, M Zaider. Automated planning volume definition in soft-tissue sarcoma adjuvant brachytherapy. Physics in Medicine and Biology. 2002; 47(11):1891-1910.

EK Lee, M Zaider. On the determination of an effective planning volume for permanent prostate implants. International Journal of Radiation Oncology, Biology and Physics. 2001; 49(4):1197-1206.

EK Lee, T Fox, I Crocker. Optimization of radiosurgery treatment planning via mixed integer programming. Medical Physics. 2000; 27(5):995-1004.

M Zaider, MJ Zelefsky, EK Lee, KL Zakian, HI Amols, J Dyke, G Cohen, YC Hu, AK Endi, CS Chui, JA Koutcher. Treatment planning for prostate implants using magnetic-resonance spectroscopy imaging. International Journal of Radiation Oncology, Biology and Physics. 2000; 47(4):1085-96.

CS Wuu, RD Ennis, PB Schiff, EK Lee, M Zaider. Dosimetric and volumetric criteria for selecting a source activity and a source type (I-125 or Pd-103) in the presence of irregular seed placement in permanent prostate implants. International Journal of Radiation Oncology, Biology and Physics. 2000; 47(3):815-820.

EK Lee, RJ Gallagher, M Zaider. Planning implants of radionuclides for the treatment of prostate cancer: An application of mixed integer programming. OPTIMA, Mathematical Programming Society Newsletter. 1999; 61:1-10.

EK Lee, RJ Gallagher, D Silvern, CS Wuu, M Zaider. Treatment planning for brachytherapy: An integer programming model, two computational approaches and experiments with permanent prostate implant planning. Physics in Medicine and Biology. 1999; 44(1):145-165.

EK Lee, D Silvern, R Gallagher, LG Stabile, RD Ennis, CR Moorthy, M Zaider. Treatment planning for permanent prostate implants: Genetic algorithm versus integer programming. Medical & Biological Engineering & Computing. 1997; 35:Supplement Part 2.

RJ Gallagher, EK Lee. Mixed integer programming optimization models for brachytherapy treatment planning. In DR Masys, Ed. Proceedings of the 1997 American Medical Informatics Association Annual Fall Symposium. 1997; 278-282.

< List of Selected Papers > < Top of Page >

BIOMEDICAL INFORMATICS, PREDICTIVE MODELS, EARLY DIAGNOSIS, OUTCOME PREDICTION

HI Nakaya, J Wrammert, EK Lee, L Racioppi, S Marie-Kunze, WN Haining, AR Means, SP Kasturi, N Khan, GM Li, M McCausland, V Kanchan, KE Kokko, S Li, R Elbein, AK Mehta, A Aderem, K Subbarao, R Ahmed, B Pulendran. Systems biology of vaccination for seasonal influenza in humans. Nature Immunology. 2011; 12:786–795.

EK Lee, HR Lee, A Quarshie. SEACOIN — An investigative tool for biomedical informatics researchers. American Medical Informatics Association 2011 Symposium Proceedings. 2011; 750-759.

EK Lee, AF Mejia, T Senior, J Jose. Improving patient safety through medical alert management: An automated decision tool to reduce alert fatigue. American Medical Informatics Association 2010 Symposium Proceedings. 2010; 417-421.

EK Lee, CH Chen, F Pietz, B Benecke. Disease propagation analysis and mitigation strategies for effective mass dispensing. American Medical Informatics Association 2010 Symposium Proceedings. 2010; 427-431.

MS Hagen, EK Lee. BIOSPIDA: A relational database translator for NCBI. American Medical Informatics Association 2010 Symposium Proceedings. 2010; 422-426.

EK Lee, K Cha. Automated data collection and integration for cancer treatment design and clinical quality evaluation investigations. 2010 AMIA Summit on Clinical Research Informatics, San Francisco, CA. Mar 2010.

JP Brooks, EK Lee. Analysis of the consistency of a mixed integer programming-based multi-category constrained discriminant model. Annals of Operations Research on Data Mining. 2010; 174(1):147-168.

MT McCabe, EK Lee, PM Vertino. A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation. Cancer Research. 2009; 69(1):282-291.

TD Querec, RS Akondy, EK Lee, W Cao, HI Nakaya, D Teuwen, A Pirani, K Gernert, J Deng, B Marzolf, K Kennedy, H Wu, S Bennouna, H Olouch, J Miller, RZ Vencio, M Mulligan, A Aderem, R Ahmed, B Pulendran. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nature Immunology. 2009; 10(1):116-125.

EK Lee. Machine learning framework for classification in medicine and biology. Integration of AI and OR techniques in constraint programming for combinatorial optimization problems, 6th International Conference, CPAIOR 2009, Proceedings (plenary speaker). In WJ van Hoeve, JN Hooker, Eds. Lecture Notes in Computer Science. 2009; 5547:1-7.

Q Lin, C Pu, EK Lee. A model-driven approach to manage evolving clinical and translational data in relational databases. IEEE International Conference on Bioinformatics and Biomeidcine Workshops (BIBMW), 2008. 2008; 109-110.

EK Lee, Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering -- Systems Biology, Bioinformatics, and Computational Biology, 35(6):1095-1109, 2007.

EK Lee, TL Wu. Classification and disease prediction via mathematical programming. In: O Seref, OE Kundakcioglu, PM Pardalos, eds. Data Mining, Systems Analysis and Optimization in Biomedicine. AIP Conference Proceedings. 2007; 953:1-42.

EK Lee, Optimization-Based Predictive Models in Medicine and Biology. Optimization in Medicine, Springer Netherlands, Springer Series in Optimization and Its Application, 12: 127-151, 2007.

EK Lee, T Easton, K Gupta. Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research, Operations Research in Medicine—Computing and Optimization in Medicine and Life Sciences. 2006; 148(1):167-187.

FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino. DNA motifs associated with aberrant CpG island methylation. Genomics. 2006; 87(5):572-579.

EK Lee, RJ Gallagher, AM Campbell, MR Prausnitz. Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra. IEEE Transactions on Biomedical Engineering. 2004; 51(1):82-89.

FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino. Predicting aberrant CpG island methylation. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(21):12253-12258.

EK Lee, RJ Gallagher, DA Patterson. A linear programming approach to discriminant analysis with a reserved-judgment region. INFORMS Journal on Computing. 2003; 15(1):23-41.

RJ Gallagher, EK Lee, DA Patterson. Constrained discriminant analysis via 0/1 mixed integer programming. Annals of Operations Research, Special Issue on Non-Traditional Approaches to Statistical Classification and Regression. 1997; 74:65-88.

RJ Gallagher, EK Lee, DA Patterson. An optimization model for constrained discriminant analysis and numerical experiments with iris, thyroid, and heart disease datasets. In JJ Cimino, Ed. Proceedings of the 1996 American Medical Informatics Association Annual Fall Symposium. 1996; 209-213.

EK Lee, RJ Gallagher, DA Patterson. Mixed integer programming models for machine learning and discriminant analysis. Proceedings of ICIAM. 1995.

< List of Selected Papers > < Top of Page >

LARGE-SCALE OPTIMIZATION (THEORY AND COMPUTATION) AND LOGISTICS

EK Lee, CH Chen, F Pietz, B Benecke. Disease propagation analysis and mitigation strategies for effective mass dispensing. American Medical Informatics Association 2010 Symposium Proceedings. 2010; 427-431.

JP Brooks, EK Lee. Analysis of the consistency of a mixed integer programming-based multi-category constrained discriminant model. Annals of Operations Research on Data Mining. 2010; 174(1):147-168.

EK Lee, CH Chen, F Pietz, B Benecke. Modeling and optimizing the public-health infrastructure for emergency response. Interfaces — 2008 Wagner Prize Special Issue. 2009; 39(5):476-490.

EK Lee, HK Smalley, Y Zhang, F Pietz, B Benecke. Facility location and multi-modality mass dispensing strategies and emergency response for biodefense and infectious disease outbreaks. International Journal on Risk Assessment and Management — Biosecurity Assurance in a Threatening World: Challenges, Explorations, and Breakthroughs. 2009; 12(2/3/4):311-351.

EK Lee, S Maheshwary. Facets of conflict hypergraphs. Submitted.

EK Lee. Modeling and optimizing the public health infrastructure for emergency response. Modeling and Simulation for Emergency Management and Health Care Systems: Workshop Summary, US Department of Commerce and National Institute of Standards and Technology. 2008.

EK Lee, M Zaider. Operations research advances cancer therapeutics. Interfaces — 2007 Franz Edelman Prize Special Issue. 2008; 38(1):5-25.

JP Brooks, EK Lee. Solving a mixed integer programming multi-category classification model with misclassification constraints. Submitted.

EK Lee, Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering -- Systems Biology, Bioinformatics, and Computational Biology, 35(6):1095-1109, 2007.

EK Lee, TL Wu. Classification and disease prediction via mathematical programming. In: O Seref, OE Kundakcioglu, PM Pardalos, eds. Data Mining, Systems Analysis and Optimization in Biomedicine. AIP Conference Proceedings. 2007; 953:1-42.

EK Lee, Optimization-Based Predictive Models in Medicine and Biology. Optimization in Medicine, Springer Netherlands, Springer Series in Optimization and Its Application, 12: 127-151, 2007.

JP Brooks and EK Lee, Mixed integer programming constrained discrimination model for credit screening. In Proceedings of the 2007 Spring Simulation Multiconference, Business and Industry Symposium, 1-6, Norfolk, VA, Mar 2007. ACM Digital Library.

JP Brooks, EK Lee. Solving a mixed-integer programming formulation of a multi-category constrained discrimination model. In Proceedings of the 2006 INFORMS Workshop on Artificial Intelligence and Data Mining, 1-6. Pittsburgh, PA. November 2006.

EK Lee, S Maheshwary, J Mason, W Glisson. Large-scale dispensing for emergency response to bioterrorism and infectious-disease outbreak. Interfaces—OR Applications for Homeland Defense. 2006; 36(6):591-607.

EK Lee, S Maheshwary, J Mason, W Glisson. Decision support system for mass dispensing of medications for infectious disease outbreaks and bioterrorist attacks. Annals of Operations Research, Operations Research in Medicine—Computing and Optimization in Medicine and Life Sciences. 2006; 148(1):25-53.

JCC Tsai, VCP Chen, EK Lee, EL Johnson. Parallelization of the MARS value function approximation in a decision-making framework for wastewater treatment. Computational Statistics and Data Analysis. COSMOS Technical Report 03-02. 2005.

EK Lee. Generating cutting planes for mixed integer programming problems in a parallel computing environment. INFORMS Journal on Computing. 2004; 16(1):3-26.

T Easton, K Hooker, EK Lee. Facets of the independent set polytope. Mathematical Programming Series B. 2003; 98(1-3):177-199.

JJ Bartholdi III, D Dave, EK Lee. Computing optimal load plans in less-than-truckload freight networks. Advances in Manufacturing, Logistics, and Supply Chain Management: Proceedings of the International Workshop in IT-Enabled Manufacturing, Logistics, and Supply Chain Management, Bangalore, India. 2003; 1-22.

EK Lee, RJ Gallagher, DA Patterson. A linear programming approach to discriminant analysis with a reserved-judgment region. INFORMS Journal on Computing. 2003; 15(1):23-41.

JT Linderoth, EK Lee, MWP Savelsbergh. A parallel, linear programming-based heuristic for large-scale set partitioning problems. INFORMS Journal on Computing. 2001; 13(3):191-209.

EK Lee. A linear-programming based parallel cutting plane algorithm for mixed integer programming problems. Proceeding for the Third Scandinavian Workshop on Linear Programming. 1999; 22-31.

RE Bixby, W Cook, A Cox, EK Lee. Computational experience with parallel mixed integer programming in a distributed environment. Annals of Operations Research — Parallel Optimization. 1999; 90:19-43.

EK Lee, JE Mitchell. Computational experience of an interior-point SQP algorithm in a parallel branch-and-bound framework. In H Frenk, K Roos, T Terlaky, S Zhang, eds. Conference Proceedings High Performance Optimization II. 1997. Kluwer Academic Publishers. 1999; 329-347.

EK Lee, J Mitchell, Computational experience of an interior-point algorithm in a parallel branch-and-cut framework. Proceedings for SIAM Conference on Parallel Processing for Scientific Computing, 1-9, 1997.

M Junger, EK Lee, P Mutzel, T Odenthal. A polyhedral approach to the multi-layer crossing minimization problem. Proceedings of the International Symposium on Graph Drawing. Lecture Notes in Computer Science, LNCS. Springer-Verlag. 1997; 1353:13-24.

RJ Gallagher, EK Lee, DA Patterson. Constrained discriminant analysis via 0/1 mixed integer programming. Annals of Operations Research, Special Issue on Non-Traditional Approaches to Statistical Classification and Regression. 1997; 74:65-88.

EK Lee. On facets of knapsack equality polytopes. Journal of Optimization Theory and Applications. 1997; 94(1):223-239.

EK Lee, JE Mitchell. Computational experience in nonlinear mixed integer programming. The Operations Research Proceedings, Springer. 1996; 95-100.

RE Bixby, EK Lee, Solving a truck dispatching scheduling problem using branch-and-cut, Operations Research, 46(3): 355-367, 1994.

< List of Selected Papers > < Top of Page >

REVIEWED BIOLOGICAL / MEDICAL ABSTRACTS

EK Lee, F Yuan, R Yao, J Chu. PET-image TCP-driven biological planning for cervical cancer high dose rate brachytherapy. Medical Physics. 2011; 38(6):3637.

EK Lee, K Cha, J Deasy, C Hamilton. Handling multiple clinical objectives in intensity-modulated radiation therapy treatment planning. Medical Physics. 2010; 37(6): 3214.

J Zhou, J Turian, EK Lee, A Templeton, Y Liao, J Chu. A Novel Approach to tracking intrafraction prostate motion during volumetric modulated arc therapy with tomosynthesis. Medical Physics. 2010; 37(6): 3386.

EK Lee, K Cha. An image-guided adaptive treatment planning optimization for IMRT. Medical Physics. 2009; 36(6): 2538.

EK Lee, F Yuan, A Templeton, R Yao, JC Chu. PET image-guided dose escalation in high-dose rate radiation therapy. International Journal of Radiation Oncology, Biology and Physics. 2010; 78(3):Supplement(Proceedings of the 52nd Annual ASTRO Meeting),S415.

EK Lee, K Cha, and M Zaider. Automated planning volume definition for HDR brachytherapy: Application to intraluminal treatment of the bile duct. Medical Physics. 2009; 36(6):2530.

MT McCabe, EK Lee, PM Vertino, Multi-factorial prediction of aberrant CpG island methylation in cancer. AACR Special Conference Cancer Epigenetics (Boston, MA). 2008; A73.

EK Lee, K Cha, T Bortfeld, J Deasy. Robust optimization to accommodate effects of systematic treatment uncertainties. 2007; 34(6):2523-2524.

MT McCabe, EK Lee, PM Vertino. Predicting methylation-prone CpG islands in human cancer. Proceedings of the American Association for Cancer Research. 2007; 48:Abs 2839

MT McCabe, EK Lee, PM Vertino. Multi-Factorial prediction of aberrant CpG island methylation in Cancer. The Sixth Georgia Tech; Oak Ridge International Conference on Bioinformatics. In silico Biology: Gene Discovery and Systems Genomics. 2007, 35.

EK Lee, K Cha, JO Deasy. Robust optimization to accommodate effects of systematic treatment uncertainties. Proceedings for International Conference on The Use of Computers in Radiation Therapy. 2007; 6256:1-5.

EK Lee, K Cha, T Bortfeld, JO Deasy. 4D-image-guided treatment planning optimization for management of organ motion in radiotherapy planning. Medical Physics. 2006; 33(6):2190-2191.

EK Lee. Large-scale pattern recognition and classification approaches for disease diagnosis. Biomedical Engineering Systems Biology and Bioinformatics. 2006.

EK Lee, M Zaider. Incorporating biological metabolite information within treatment of prostate carcinoma and analysis of dose escalation effect. International Journal of Radiation Oncology, Biology and Physics. 2006; 66(3):Supplement(Proceedings of the 48th Annual ASTRO Meeting),S572-S573.

EK Lee, K Cha, T Bortfeld, JO Deasy. 4D-image-guided treatment planning optimization for managing organ motion in radiotherapy planning. Proceedings for International Conference on The Use of Computers in Radiation Therapy. 2007; 6205:1-5.

EK Lee, DP Lewis, K Cha. Efficient IMRT delivery; Fast generation of integer-valued beam profiles. Medical Physics, 33: 2096, 2006.

PK Mehta, L Simpson, EK Lee, TA Lyle, WM Book. Endothelin-receptor antagonists improve exercise tolerance and oxygen saturations in adults with the Eisenmenger syndrome. American Heart Association Scientific Sessions 3190. Nov 2005.

EK Lee, T Easton, K Gupta. Novel evolutionary models and applications to the sequence alignment problems. The Fifth Georgia Tech; Oak Ridge National Lab International Conference on Bioinformatics: In Silico Biology, Computational Genomics and Evolutionary Biology. Nov 2005; 63.

EK Lee, FA Feltus, JF Costello, C Plass, PM Vertino. Large-scale genomic pattern recognition and classification of aberrantly hypermethylated CpG island loci in human cancer. The Fifth Georgia Tech; Oak Ridge National Lab International Conference on Bioinformatics: In Silico Biology, Computational Genomics and Evolutionary Biology. Nov 2005; 62.

FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino. DNA patterns associated with CpG island methylation state. The Fifth Georgia Tech;Oak Ridge National Lab International Conference on Bioinformatics: In Silico Biology, Computational Genomics and Evolutionary Biology. Nov 2005; 50.

EK Lee, K Cha, T Bortfeld, JO Deasy, TL Wu. Multistage treatment planning optimization for managing organ motion in radiotherapy planning. International Journal of Radiation Oncology, Biology and Physics. 2005; 63:Supplement 1(Proceedings of the 47th Annual ASTRO Meeting),S209-S210.

EK Lee, K Cha, T Bortfeld, JO Deasy. Multistage treatment planning optimization for managing organ motion in radiotherapy planning. Medical Physics. 2005; 32(6):1925.

EK Lee, T Bortfeld, JO Deasy. Robust optimization including effects of systematic treatment errors. Medical Physics. 2005; 32(6):1978.

EK Lee, D Lewis. Fast integer-valued smoothing of beam profiles in intensity modulated radiation therapy. Medical Physics. 2005; 32(6):1974.

EK Lee, M Zaider. Incorporating biological metabolite information within treatment of prostate carcinoma. International Journal of Radiation Oncology, Biology and Physics. 2004; 60(1):Supplement(Proceedings of the 46th Annual ASTRO Meeting),S371-372.

EK Lee, K Cha, J Shi. Automated data collection and integration for cancer treatment design and clinical quality evaluation investigation. Joint BECON/BISTIC 2004 Symposium Biomedical Informatics for Clinical Decision Support: A Vision for the 21st Century, NIH Bethesda. Jun 2004; 23.

EK Lee. Optimization techniques and their suitability and robustness for IMRT planning. Invited presentation at 46th American Association of Physicists in Medicine Annual Meeting Pittsburgh 2004. Medical Physics. 2004; 31(6):1762.

EK Lee. Handling multiple clinical objectives in intensity modulated radiation therapy treatment planning.Abstract selected for oral presentation at 46th American Association of Physicists in Medicine Annual Meeting Pittsburgh 2004. Medical Physics. 2004; 31(6):1777.

J Deasy, EK Lee, M Langer, T Bortfeld, Y Zhang, H Liu, R Mohan, R Ahuja, J Dempsey, A Pollack, J Rosenman, A Eisbruch, R Rardin, J Purdy, C Zakarian, J Alaly. An IMRT treatment planning research collaboratory. Abstract selected for oral presentation at 46th American Association of Physicists in Medicine Annual Meeting Pittsburgh 2004. Medical Physics. 2004; 31(6):1775.

JC Landry, M Koshy, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis. Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction. Proceedings of American Society of Clinical Oncology. 2003; 22..

EK Lee, T Fox, I Crocker. Beam geometry and intensity map optimization in IMRT via computational optimization. Abstract selected for oral presentation at AAPM San Diego July 2003. Medical Physics. 2003; 30(6):1385-1386.

EK Lee, JO Deasy, I El Naqa, I Kawrakow, M Vicic. Integrating a Monte Carlo based optimization module into CERR for designing IMRT plans. Abstract selected for presentation at AAPM San Diego July 2003. Medical Physics. 2003; 30(6):1324.

M Koshy, JC Landry, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis. Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction. American Radium Society Houston, Texas. Cancer Journal Scientific American. 2003.

EK Lee, R Wagman, M Zaider. Treatment planning with automated planning volume definition for HDR brachytherapy -- Application to intraluminal treatment of the bile duct. International Conference on Translational Research and Pre-Clinical Strategies in Clinical Radio-Oncology, ICTR 2003 Advances In Translational Radiation Oncology: From Molecular Signalling to Cancer Cure. March 2003.

EK Lee, M Zaider. Intra-operative dynamic dose optimization in permanent prostate implants.International Conference on Translational Research and Pre-Clinical Strategies in Clinical Radio-Oncology, ICTR 2003 Advances In Translational Radiation Oncology: From Molecular Signalling to Cancer Cure. March 2003.

FA Feltus, JF Costello, C Plass, EK Lee, PM Vertino. Identifying sequence patterns associated with aberrant CpG island methylation. Proceedings of American Association of Cancer Research. 2002; LB:3.

EK Lee, M Zaider. Intra-operative dynamic dose optimization for prostate permanent implants. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics. 2002; 29(6): 1228.

EK Lee, T Fox, I Crocker. Mixed integer programming techniques applied to IMRT treatment planning optimization. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics. 2002; 29(6):1259.

JO Deasy, EK Lee, I Kawrakow, C Zakarian. A prototype Monte Carlo-based IMRT treatment planning research system. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics. 2002; 29(6):1254.

EK Lee, K Godette, C Anderson, J Keller. Effect of race and radiation treatment modalities on biochemical failure in prostate cancer cases. 44th American Association of Physicists in Medicine Annual Meeting. Medical Physics. 2002; 29(6):Supplement.

EK Lee, AY Fung, M Zaider. Automated planning volume contouring in soft-tissue sarcoma adjuvant brachytherapy treatment. International Journal of Radiation Oncology, Biology and Physics. 2001; 51(3):Supplement 1(Proceedings of the 43rd Annual ASTRO Meeting),391.

EK Lee, T Fox, I Crocker. Computational optimization for brain tumor radiosurgery treatment planning. 43rd American Association of Physicists in Medicine Annual Meeting. Medical Physics. 2001; 28(6):1304.

EK Lee. An innovative computerized treatment planning system for permanent prostate implants. The American Association for the Advancement of Science 2001 Annual Meeting; Science Innovation Exposition (Invited presentation with media briefings). February 2001; A41.

EK Lee, M Zaider. Intra-operative iterative treatment-plan optimization for prostate permanent implants. 2nd International Innovative Solutions for Prostate Cancer Care meeting. 2001; 32-33.

M Zaider, EK Lee. MRS-guided dose-escalation treatment planning optimization for permanent prostate implants. 2nd International Innovative Solutions for Prostate Cancer Care meeting. 2001; 36.

M Zaider, EK Lee, K Zakian, HA Amols, M Zelefsky, J Dyke, J Koutcher. Intensity-modulated conformal treatment planning for prostate implants using magnetic resonance spectroscopy. International Journal of Radiation Oncology, Biology and Physics. 1999; 45(3):Supplement(Proceedings of the 41st Annual ASTRO Meeting),351.

EK Lee, M Zaider, M Zelefsky. On the definition of effective planning volume in permanent prostate implants. International Journal of Radiation Oncology, Biology and Physics. 1999; 45(3):Supplement(Prodeedings of the 41st Annual ASTRO Meeting), 261-262

DA Silvern, EK Lee, RJ Gallagher, LG Stabile, RD Ennis, CR Moorthy, M Zaider. Treatment planning for permanent prostate implants: Genetic algorithm versus integer programming. Medical; Biological Engineering; Computing. 1997; 35:Supplement Part 2,850.

RE Bixby, W Cook, A Cox, EK Lee. Parallel mixed integer programming. Center for Research on Parallel Computation. Research Monograph CRPC-TR95554. 1995.

< List of Selected Papers > < Top of Page >

PUBLISHED BOOKS

GJ Lim, EK Lee, eds. Optimization in Medicine and Biology. Boca Raton, FL: Auerbach Publications, Taylor; Francis Group; 2008..

EK Lee, A Sofer, eds. Annals of Operations Research, Vol 148, Operations Research in Medicine;Computing and Optimization in Medicine and Life Sciences. The Netherlands: Springer; 2006.

EK Lee, A Sofer, eds. Annals of Operations Research, Vol 119, Computational Approaches to Medical and Life Sciences Applications. The Netherlands: Kluwer Academic Publishers; 2003.

REFEREED PUBLISHED BOOK CHAPTERS

EK Lee, AY Yang, F Pietz, B Benecke. Public health, emergency response, and medical preparedness IV: Emergency evacuation. In: JJ Cochran, ed in chief. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley; 2011.

EK Lee, F Pietz, B Benecke. Public health, emergency response, and medical preparedness II: Medical countermeasures dispensing and large-scale disaster relief efforts. In: JJ Cochran, ed in chief. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley; 2011.

EK Lee, AY Yang, T Guilford, F Pietz, B Benecke. Public health, emergency response, and medical preparedness III: Communication infrastructure. In: JJ Cochran, ed in chief. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley; 2011.

EK Lee, AY Yang, F Pietz, B Benecke. Public health, emergency response, and medical preparedness IV: Emergency Evacuation. In: JJ Cochran, ed in chief. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley; 2011

EK Lee, AY Yang, F Pietz, B Benecke.Public health, emergency response, and medical preparedness I: Medical surge. In: JJ Cochran, ed in chief. Wiley Encyclopedia of Operations Research and Management Science. Hoboken, NJ: Wiley; 2011.

EK Lee, AY Yang, F Pietz, B Benecke. Public health and medical preparedness. In: Y Yih, ed. Handbook of Healthcare Delivery Systems. Boca Raton, FL: CRC Press, Taylor; Francis Group; 2011.

EK Lee, K Gupta. Algorithms for genomics analysis. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. 2nd ed. The Netherlands: Springer; 2009:33-54.

EK Lee, TL Wu. Disease diagnosis: Optimization-based methods. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. 2nd ed. The Netherlands: Springer; 2009:753-784.

EK Lee, JE Mitchell. Integer programming: Branch-and-bound methods. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. 2nd ed. The Netherlands: Springer; 2009:1634-1643.

EK Lee, TL Wu. Classification and disease prediction via mathematical programming. In: PM Pardalos, HE Romeijn, eds. Handbook of Optimization in Medicine, Chapter 12. Springer Optimization and Its Applications, Vol 26. The Netherlands: Springer; 2009:381-430.

EK Lee, K Gupta. Algorithms for genomics analysis. In: PM Pardalos, HE Romeijn, eds. Handbook of Optimization in Medicine, Chapter 9. Springer Optimization and Its Applications, Vol 26. The Netherlands: Springer; 2009:291-323.

EK Lee, TL Wu, JP Brooks. Classification and disease prediction via mathematical programming. Classification and disease prediction via mathematical programming. In: GJ Lim, EK Lee, eds. Optimization in Medicine and Biology, Chapter 1. Boca Raton, FL: Auerbach Publications, Taylor; Francis Group; 2008:3-60.

EK Lee, K Gupta. Algorithms for genomics analysis. In: GJ Lim, EK Lee, eds. Optimization in Medicine and Biology, Chapter 12. Boca Raton, FL: Auerbach Publications, Taylor; Francis Group; 2008:355-393.

EK Lee, DP Lewis. Integer programming for telecommunications. In: MGC Resende, PM Pardalos, eds. Handbook of Optimization in Telecommunications, Chapter 3. The Netherlands: Springer; 2006:67-102.

EK Lee, M Zaider. Optimization and decision support in brachytherapy treatment planning. In: ML Brandeau, F Sainfort, WP Pierskalla, eds. Operations Research and Health Care: A Handbook of Methods and Applications, Chapter 28. International Series in Operations Research; Management Science, Vol 70. The Netherlands: Kluwer Academic Publishers; 2004.

M Zaider, EK Lee. Treatment planning for low dose rate and high dose rate brachytherapy. In: AP Dicker, GS Merrick, FM Waterman, RK Valicenti, LG Gomella, eds. Basic and Advanced Techniques in Prostate Brachytherapy, Chapter 12. The United Kingdom: Taylor; Francis Group; 2005.

EK Lee. Branch-and-bound methods. In: PM Pardalos, MGC Resende, eds. Handbook of Applied Optimization, Chapter 3, Section 2. New York, NY: Oxford University Press USA; 2002. (Honorable mention by the Association of American Publishers' Outstanding Professional and Scholarly Titles of 2002 in Computer Science.)

EK Lee, JE Mitchell. Integer programming: Branch and bound methods. In: CA Floudas, PM Pardalos, eds. Encyclopedia of Optimization. The Netherlands: Kluwer Academic Publishers; 2001:1049-1059.

< List of Selected Papers > < Top of Page >

Courses

  • Spring 1996. (Columbia) IEOR 6608 Integer Programming
  • Spring 1997. (Columbia) IEOR 4600 Applied Integer Programming
  • Spring 1997. (Columbia) IEOR 4004 Introduction to Operations Research -- Deterministic Models
  • Fall 1997. ISyE 3231 Deterministic Operations Research
  • Winter 1998. ISyE 6662 Optimization II -- Part II:Integer Programming
  • Fall 1998. ISyE 3231 Deterministic Operations Research
  • Spring 2000 ISyE 4803 Topics in Optimization -- Applications to Real-World Problems
  • Spring 2001 ISyE 4104 Senior Design
  • Spring 2002. ISyE 6662 Optimization II
  • Fall 2002. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
  • Spring 2003. ISyE 4231 Engineering Optimization (Section B)
  • Fall 2003. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
  • Spring 2004. ISyE 4231 Engineering Optimization (Section C)
  • Fall 2004. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2004. BIOL 8802 Topics in Bioinformatics -- Lectures on Cancer Bioinformatics and Predictive Models in Disease Diagnosis
  • Spring 2005. ISyE 4231 Engineering Optimization (Section C)
  • Fall 2005. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2006. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2006. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2007. ISyE 3133 Engineering Optimization (Section B)
  • Spring 2007. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2007. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2008. ISyE 6679 Computational Methods
  • Spring 2008. ISyE 4601 Senior Design
  • Spring 2008 (Emory). BIOS 509 Biomedical Informatics in Clinical Research
  • Fall 2008. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2009. ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2009. BIOL 8803/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Predictive Modeling
  • Spring 2010. ISyE 6679 Computational Methods
  • Spring 2010. ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2010. ISyE 6679 Computational Methods
  • Fall 2010. BIOL 7015/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Predictive Modeling
  • Spring 2011. ISyE 4803/8813/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2011. BIOL 7015/ISyE 8813/BIOL 4015 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Predictive Modeling

Hobbies

< Top of Page >