Photo of Professor Lee, November 2005

Eva K. Lee

Associate Professor
Director, Center for Operations Research in Medicine and HealthCare
School of Industrial and Systems Engineering
Georgia Institute of Technology
Atlanta, GA 30332-0205
Phone: (404) 894-4962
Fax: (404) 894-2301
photo
Associate Professor
Winship Cancer Institute
School of Medicine
Emory University
Personal Biosketch


Affiliations

Research Interests

  • Large-Scale Optimization: Linear/Nonlinear mixed integer programming -- polyhedral theory, algorithmic design and parallel implementation
  • Theory and Algorithms for Combinatorial Optimization Problems
  • Mathematical Modeling, Informatics, and Computational Advances for Bio/medical and Healthcare Research -- 1) genomic analysis; 2) health risk prediction and disease diagnosis; 3) optimal treatment design and drug delivery; 4) early detection, target intervention, monitoring and controlling of disease, and treatment outcome prediction; 5) public health and medical preparedness; and 6) healthcare operations and logistics.
  • Large-scale Logistics -- Emergency response and resource allocation for bioterrorism and infectious disease outbreaks, finance portfolio optimization
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Current Projects

    Large-scale Optimization and Logistics

    • Mixed integer programming: polyhedral theory, algorithmic design and parallel implementation.
    • Decision support system for mass dispensing for pandemics and bioterror attacks.
    • Efficient models and algorithms for finance portfolio optimization.

    Bio/medical, Healthcare and Public Health Research

    • Machine learning and predictive models -- Pattern recognition and discriminant analysis approaches to health risk prediction, medical diagnosis, early detection, target intervention, monitoring and controlling of disease, and treatment outcome prediction.
    • Public health and medical preparedness -- decision analysis of strategic and operational planning for mass dispensing for pandemics, bioterror, and population health monitoring in radiogical attacks.
    • Large-scale cancer modeling and biocomputing intensity-modulated radiation therapy -- To produce IMRT treatment plans, sophisticated optimization methods must be used for designing the optimal beam geometry, fluence pattern and delivery parameters. This research explores novel optimization and biological models, and large-scale parallel algorithms for real-time clinically relevant plan design. Furthermore, issues related to organ motion and continuous tumor shrinkage are investigated.
    • Evolutionary models, DNA sequencing and genomic analysis -- Development of efficient mathematical models and robust algorithms for large-scale sequence analysis problems arising in computational genomics, protein structural analysis, and evolutionary biology.
    • Biological modeling and large-scale computing for multi-modality optimal cancer treatment design for permanent implants in radiation therapy -- Development of optimization models and expert online treatment planning system for determining optimal configuration for radioactive seed implants. One of the goals involves incorporating biologic tumor information into planning procedures (e.g., brachytherapy, IMRT) in the treatment of prostate carcinoma to improve local tumor control by emphasizing not only the clinical prescribed dose but also appropriate escalated dose within the prostate.
    • Brain Tumor Radiosurgery Treatment Planning -- Development of sophisticated models for deriving the clinical parameters for determining optimal treatment plans for brain tumor radiosurgery (i.e., high dose, high precision external beam radiation therapy). Clinical expert system encapsulates the optimization module to assist neurosurgeons in the treatment delivery room.
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Selected Papers

Optimization and Logistics

< List of Selected Papers > < Top of Page >

Medical, HealthCare, Public Health

  • EK Lee, M Zaider, Operations Research Advances Cancer Therapeutics. Interface. To appear 2008.
  • EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Data Mining, Systems Analysis, and Optimization in Biomedicine. Editors: O Seref, OE Kundakcioglu and P Pardalos. AIP Conference Proceedings 953:1-42, 2007.
  • P Mehta, L Simpson, EK Lee, T Lyle, W Book, Endothelin Receptor Antagonits Improve Exercise Tolerance and Oxygen Saturations in Patients with Pulmonary Arterial Hypertension and Congenital Heart Defects, Congenital Heart Disease. Texas Heart Institute Journal. Accepted Oct 2007.
  • A Jayashankar, U Udayasankar, S Sebastian, M Kalra, EK Lee, W Small, MDCT of Thoraco-Abdominal Trauma: An Evaluation of the Success and Limitations of Primary Interpretation Using Multiplanar Reformatted Images versus Axial Images. Emergency Radiology. Accepted Aug 2007.
  • EK Lee, Optimization-Based Predictive Models in Medicine and Biology. Optimization in Medicine, Springer Netherlands, Springer Series in Optimization and Its Application, 12: 127-151, 2007.
  • EK Lee, Large-scale optimization-based classification models in medicine and biology. Annals of Biomedical Engineering, Systems Biology and Bioinformatics 35(6): 1095-1109, 2007.
  • EK Lee, KD Cha, T Bortfeld, JO Deasy, 4D-Image-Guided Treatment Planning Optimization for Managing Organ Motion in Radiotherapy Planning. International Conference on The Use of Computers in Radiation Therapy. 2007.
  • EK Lee, KD Cha, JO Deasy, Robust Optimization to Accommodate Effects of Systematic Treatment Uncertainties. International Conference on The Use of Computers in Radiation Therapy. 2007.
  • EK Lee, DP Lewis, KD Cha, Fast Generation of Integer-Valued Beam Profiles for Intensity Modulated Radiation Therapy. Medical Physics. Submitted.
  • EK Lee, S Maheshwary, J Mason, W Glisson, Large-scale dispensing for emergency response to bioterrorism & infectious disease outbreak. Interfaces -- OR Applications for Homeland Defense 36(6): 591-607, 2006.
  • FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, DNA Motifs Associated with aberrant CpG Island methylation, Genomics, 87: 572-579, 2006.
  • EK Lee, T Fox, I Crocker, Simultaneous beam geometry and intensity map optimization in intensity-modulated radiation therapy. International Journal of Radiation Oncology, Biology and Physics 64(1): 301-320, 2006.
  • J Deasy, EK Lee, T Bortfeld, M Langer, K Zakarian, J Alaly, Y Zhang, H Liu, R Mohan, R Ahuja, A Pollack, J Purdy, R Rardin, A collaboratory for radiation therapy treatment planning optimization research, Annals of Operations Research, Operations Research in Medicine -- Computing and Optimization in Medicine and Life Sciences 148: 55-63, 2006.
  • EK Lee, T Easton, K Gupta, Novel evolutionary models and applications to sequence alignment problems. Annals of Operations Research, Operations Research in Medicine -- Computing and Optimization in Medicine and Life Sciences, 148: 167-187, 2006.
  • EK Lee, S Maheshwary, J Mason, Emergency response decision support system for infectious disease outbreak and biodefense. Annals of Operations Research, Operations Research in Medicine -- Computing and Optimization in Medicine and Life Sciences 148: 25-53, 2006.
  • EK Lee, JO Deasy, Optimization in intensity-modulated radiation therapy. SIAG/OPT Views-and-News, Optimization in Medicine, 17(2): 20-32, 2006.
  • EK Lee, S Maheshwary, J Mason, Emergency treatment response and real-time staff allocation for bioterrorism and infectious disease outbreak. The INFORMS William Pierskalla Best Paper Award on research excellence in HealthCare and Management Science, Nov 2005.
  • EK Lee, J Mason, and S Maheshwary, Real-Time Staff Allocation for Emergency Treatment Response of Biologic Threats and Infectious Disease Outbreak, Medical Decision Making, submitted 2004.
  • EK Lee, S Jagannathan, C Johnson, GS Galis, Fingerprinting Native and Angiogenic Microvascular Networks through Pattern Recognition and Discriminant Analysis of Functional Perfusion Data, Nature Biotechnology, submitted 2005.
  • Leo Simpson, EK Lee, Brenda J. Hott, David J. Vega and Wendy M. Book, Long-term results of angioplasty versus stenting in cardiac transplant recipients with allograft vasculopathy. The Journal of Heart and Lung Transplantation, 24(9): 1211-1217, 2005.
  • EK Lee, RJ Gallagher, A Campbell, M Prausnitz, Prediction of ultrasound-mediated disruption of cell membranes using machine learning techniques and statistical analysis of acoustic spectra, 2001. IEEE Transactions on Biomedical Engineering, 51(1): 1-9, 2004
  • M Koshy, JC Landry , JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis, IMRT for Retroperitoneal Sarcoma : A Case for Dose Escalation and Reduced Organ at Risk Toxicity Reduction, Feb 2003. Sarcoma, accepted for publication Jun 2003.
  • JC Landry, M Koshy, JD Lawson, N Esiashivilli, CA Staley, JY Ting, R Howell, S Ghavidel, EK Lee, LW Davis, Intensity modulated radiation therapy (IMRT) for retroperitoneal sarcoma: A case for dose escalation and organ at risk (OAR) toxicity reduction, Proceedings of American Society of Clinical Oncology 22: 297, 2003. Chicago Illinois, 1193.
  • EK Lee, JP Brooks, Adele Wright, C Zhu, Discriminant analysis of motility and morphology data from human lung carcinoma cells placed on purified extracellular matrix proteins, Dec 2002. Annals of Biomedical Engineering, in review.
  • FA Feltus, EK Lee, JF Costello, C Plass, PM Vertino, Predicting Aberrant CpG Island Methylation, Dec 2002. Proceedings of the National Academy of Sciences, accepted for publication Jul 2003. 100(21):12253-12258, 2003.
  • M Langer, EK Lee, JO Deasy, J Deye, R Rardin, Operations Research Applied to Radiation Therapy, Nov 2002. Int J Radiat Oncol Biol Phys., 57(3): 762-768, 2003.
  • EK Lee, J Deasy, M Langer, R Rardin, J Deye, F Mahoney, Final Report -- NCI/NSF Workshop on Operations Research Applied to Radiation Therapy. Annals of Operations Research 119: 143-146, 2003.
  • EK Lee, M Zaider, Mixed Integer Programming Approaches to Treatment Planning for Brachytherapy -- Application to Permanent Prostate Implants, subm itted Jan 2002. Annals of Operations Research (Optimization in Medicine) 119: 147-163, 2003.
  • EK Lee, T Fox, I Crocker, Integer Programming Applied to Intensity-Modulated Radiation Therapy Treatment Planning. 2001. Annals of Operations Research (Optimization in Medicine) 119: 165-181, 2003.
  • EK Lee, M Zaider, Intra-Operative Dynamic Dose Optimization in Permanent Prostate Implants. 2002. International Journal of Radiation Oncology, Biology and Physics, 56(3):854-861, 2003.
  • EK Lee, M Zaider, Determining an Effective Planning Volume for Permanent Prostate Implants. International Journal of Radiation Oncology, Biology and Physics, 49(4):1197-1206, 2001
  • EK Lee, AYC Fung, JP Brooks, M Zaider, Automated Tumor Volume Contouring in Soft-Tissue Sarcoma Adjuvant Brachytherapy Treatment, 2001. Physics in Medicine and Biology, 47 (11): 1891-1910, 2002.
  • EK Lee, T Fox, I Crocker, Optimization of Radiosurgery Treatment Planning via Mixed Integer Programming . Medical Physics. Vol. 27(5), 995-1004, 2000.
  • M Zaider, M Zelefsky, EK Lee, K Zakian, HA Amols, J Dyke, J Koutcher, Treatment Planning for Prostate Implants Using MR Spectroscopy Imaging. International Journal of Radiation Oncology, Biology and Physics, 47(4): 1085-96, 2000.
  • CS Wuu, RD Ennis, PB Schiff, EK Lee, M Zaider, Dosimetric and Volumetric Criteria for Selecting a Source Type I-125 or Pd-103 and Source Activity in the Presence of Irregular Seed Placement in Permanent Prostate Implants. International Journal of Radiation Oncology, Biology and Physics, 47: 815-820, 2000.
  • EK Lee, RJ Gallagher, D Silvern, CS Wuu, M Zaider, Treatment Planning for Brachytherapy: An Integer Programming Model, Two Computational Approaches and Experiments with Permanent Prostate Implant Planning. Physics in Medicine and Biology Vol. 44 (1), 145-165, 1999.
  • RJ Gallagher, EK Lee, Mixed Integer Programming Optimization Models for Brachytherapy Treatment Planning. In: Daniel R. Masys, Ed. Proceedings of the 1997 American Medical Informatics Association Annual Fall Symposium, 278-282, 1997.
  • RJ Gallagher, EK Lee, D Patterson, An Optimization Model for Constrained Discriminant Analysis and Numerical Experiments with Iris, Thyroid, and Heart Disease Datasets In: Cimino JJ, Ed. Proceedings of the 1996 American Medical Informatics Association Annual Fall Symposium, 209-213, 1996.
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Book and Book Chapters

  • GJ Lim and EK Lee, Optimization in Medicine and Biology, Taylor and Francis, Auerbach Publications, 564 pages, 2007.
  • EK Lee and A Sofer, Operations Research in Medicine: Computing and Optimization in Medicine and Life Sciences, Volume 2. Springer Netherlands, Computer Science Series, 270 pages, 2006.
  • EK Lee and A Sofer, Annals of Operations Research -- Optimization in Medicine: Computational and Optimization Approaches to Medical and Life Sciences Applications, Volume 1. Springer Science, Kluwer Academic Publishers, 301 pages, 2003.
  • EK Lee, TL Wu, Classification and disease prediction via mathematical programming. In Optimization in Medicine. Editors: E Romeijn and P Pardalos. Kluwer Academic Publishers, 2008, to appear.
  • EK Lee, K Gupta, Large-scale genomic analysis via combinatorial optimization. In Optimization in Medicine. Editors: E Romeijn and PM Pardalos. Kluwer Academic Publishers, 2008, to appear.
  • EK Lee, K Gupta, Algorithms for Genomics Analysis. In Encyclopedia of Optimization. Editors: Chris A. Floudas, and Panos M. Pardalos. Springer, The Netherlands 2007, to appear.
  • Disease Diagnosis: Optimization based Methods. In Encyclopedia of Optimization. Editors: Chris A. Floudas, and Panos M. Pardalos. Springer, The Netherlands 2007, to appear.
  • EK Lee, Discriminant Analysis and Predictive Models in Medicine. Interdisciplinary Research in Management Science, Finance, and HealthCare. Editor: SJ Deng. Peking University Press, 2006, to appear.
  • EK Lee, D Lewis, Integer programming for telecommunications. In Handbook of Optimization in Telecommunications, Chapter 3, 67-102. Editors: G. C. Resende and Panos M. Pardalos. Kluwer Academic Publishers, 2005.
  • EK Lee, M Zaider, Optimization and Decision Support in Brachytherapy Treatment Planning. Chapter 28 In ``Handbook of Operations Research/Management Science Applications in Health Care,'' Editors: M Bandeau, and F Sainfort. Kluwer Academic Publishers, Hillier International Series in OR/MS. 2004.
  • M Zaider, EK Lee, Treatment planning for low dose rate and high dose rate brachytherapy. In ``Basic and Advanced Techniques in Prostate Brachytherapy,'' Ed. Dicker, Merrick, Gomella, Valicenti, Waterman, Gomella. 1-84184-298-2, CRC Press, 2004.
  • EK Lee, Branch-and-Bound Methods. Invited book chapter for {Handbook of Applied Optimization}, Editors: Mauricio G. C. Resende and Panos M. Pardalos, Oxford University Press 2001, ISBN 0-19-512594-0.
  • EK Lee, J Mitchell, Branch-and-Bound Methods for Integer Programming. Invited chapter for {Encyclopedia of Optimization}, Editors: Chris A. Floudas, and Panos M. Pardalos, Kluwer Academic Publishers, The Netherlands 1999.
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Courses

  • Spring 1996. (Columbia) IEOR 6608 Integer Programming
  • Spring 1997. (Columbia) IEOR 4600 Applied Integer Programming
  • Spring 1997. (Columbia) IEOR 4004 Introduction to Operations Research -- Deterministic Models
  • Fall 1997. ISyE 3231 Deterministic Operations Research
  • Winter 1998. ISyE 6662 Optimization II -- Part II:Integer Programming
  • Fall 1998. ISyE 3231 Deterministic Operations Research
  • Spring 2000 ISyE 4803 Topics in Optimization -- Applications to Real-World Problems
  • Spring 2001 ISyE 4104 Senior Design
  • Spring 2002. ISyE 6662 Optimization II
  • Fall 2002. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
  • Spring 2003. ISyE 4231 Engineering Optimization (Section B)
  • Fall 2003. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Cancer Bioinformatics and Computing
  • Spring 2004. ISyE 4231 Engineering Optimization (Section C)
  • Fall 2004. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2004. BIOL 8802 Topics in Bioinformatics -- Lectures on Cancer Bioinformatics and Predictive Models in Disease Diagnosis
  • Spring 2005. ISyE 4231 Engineering Optimization (Section C)
  • Fall 2005. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2006. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2006. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2007. ISyE 3133 Engineering Optimization (Section B)
  • Spring 2007. ISyE 4803/HS 8803 Operations Research in Medicine and HealthCare
  • Fall 2007. BIOL 8802/ISyE 8803 Cancer Biology and Biotechnology -- Lectures on Biomedical Informatics and Large-Scale Biocomputing
  • Spring 2008. ISyE 6679 Computational Methods
  • Spring 2008. ISyE 4601 Senior Design
  • Spring 2008 (Emory). BIOS 509 Biomedical Informatics in Clinical Research

Hobbies

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